Liraglutide

Sort by

(6-31)-Liraglutide

  • CAT NUMBER DCTI-D-156
  • CAS NUMBER NA
  • MOLECULAR FORMULA C152H236N36O43
  • MOLECULAR WEIGHT 3255.77

(9-31)-Liraglutide

  • CAT NUMBER DCTI-D-157
  • CAS NUMBER NA
  • MOLECULAR FORMULA C136H215N33O38
  • MOLECULAR WEIGHT 2920.41

[3-31]-Liraglutide

  • CAT NUMBER DCTI-D-225
  • CAS NUMBER NA
  • MOLECULAR FORMULA C163H253N39O49
  • MOLECULAR WEIGHT 3543.04

[4-31]-Liraglutide

  • CAT NUMBER DCTI-D-210
  • CAS NUMBER NA
  • MOLECULAR FORMULA C158H246N38O46
  • MOLECULAR WEIGHT 3413.93

[5-31]-Liraglutide

  • CAT NUMBER DCTI-D-191
  • CAS NUMBER NA
  • MOLECULAR FORMULA C156H243N37O45
  • MOLECULAR WEIGHT 3356.87

Asn(11)-Linear Liraglutide

  • CAT NUMBER DCTI-D-304
  • CAS NUMBER NA
  • MOLECULAR FORMULA C152H229N43O47
  • MOLECULAR WEIGHT 3410.76

Asn(12)-Linear Liraglutide

  • CAT NUMBER DCTI-D-303
  • CAS NUMBER NA
  • MOLECULAR FORMULA C152H229N43O47
  • MOLECULAR WEIGHT 3410.76

Asn(8)-Linear Liraglutide

  • CAT NUMBER DCTI-D-305
  • CAS NUMBER NA
  • MOLECULAR FORMULA C152H229N43O47
  • MOLECULAR WEIGHT 3410.76

D-Allo-Thr(11)-Liraglutide

  • CAT NUMBER DCTI-D-206
  • CAS NUMBER NA
  • MOLECULAR FORMULA C172H265N43O51
  • MOLECULAR WEIGHT 3751.56
LOAD MORE
You're viewed 9 of 35 products

General Information

Liraglutide Impurities and Liraglutide 

Daicel Pharma synthesizes high-quality Liraglutide impurities, Des-Gly (29)-Liraglutide, Des-Gly (4)-Liraglutide, Des-Ser (8)-Liraglutide, Glu (17)-Liraglutide, Kyn (25)-Liraglutide, and Trp(O)-Liraglutide, which helps in quality, stability, and biological safety analysis of the API of Liraglutide. We offer custom synthesis of Liraglutide impurities and can supply globally.

Liraglutide [CAS: 204656-20-2] is a medication categorized as a Glucagon-Like Peptide-1 (GLP-1) receptor agonist. It is commonly used to treat type 2 diabetes and prevent cardiovascular complications that may arise due to diabetes.

Liraglutide: Use and Commercial Availability

Liraglutide, available under the brand name Saxenda, is used to treat chronic weight management. It aids long-term weight management in adults with obesity (BMI≥30 kg/m2) or overweight (BMI≥27 kg/m2) and at least one weight-related comorbidity such as hypertension, dysglycaemia, etc. It is indicated as an adjunct to a reduced-calorie diet.

Victoza, another brand under which Liraglutide is available, improves glycemic control in patients aged 10 or older with type 2 diabetes mellitus. It also minimizes the risk of major adverse cardiovascular events in adult patients with type 2 diabetes and established cardiovascular disease. It is available as a solution in subcutaneous injection, a pre-filled multi-dose pen that delivers doses of Liraglutide to the patients1. Liraglutide Structure and Mechanism of Action

Liraglutide Structure and Mechanism of Action

The chemical formula of Liraglutide is C172H265N43O51 and its molecular weight is approximately 3751.2 g/mol.

Liraglutide is a synthetic, acylated human glucagon-like peptide-1 (GLP-1) receptor agonist. GLP-1 receptor is present in various areas of the brain involved in appetite regulation.  It also inhibits the glucose-dependent release of glucagon and slows down gastric emptying, ultimately helping to regulate blood sugar levels more effectively.

Liraglutide Impurities and Synthesis

Liraglutide synthesis uses recombination technology in yeast and is chemically modified by the addition of the Glu-spaced hexadecanoic (palmitic) acid2 Liraglutide impurities include related substances, degradation products, residual solvents, inorganic impurities, and microbial impurities3. The manufacturers of Liraglutide perform rigorous analytical testing to detect and quantify these impurities to ensure the quality and safety of the drug.

At Daicel, we provide a Certificate of Analysis (CoA) from a cGMP-compliant analytical facility for Liraglutide impurity standards, Des-Gly (29)-Liraglutide, Des-Gly (4)-Liraglutide, Des-Ser (8)-Liraglutide, Glu (17)-Liraglutide, Kyn (25)-Liraglutide, and Trp(O)-Liraglutide, with complete characterization data including 1H NMR, 13C NMR, IR, MS3, and HPLC purity. We also provide 13C-DEPT and CHN on request. Further, we provide a complete characterization report upon delivery. Daicel offers highly pure isotope-labeled standards of Liraglutide in bioanalytical research and BA/BE studies. Bioanalytical data is vital in the development of chemical and biological drugs with isotope data in CoA.

References
FAQ's

Frequently Asked Questions

Liraglutide impurities can be identified using analytical methods such as high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS), etc.

Liraglutide impurities can be purified after synthesis using various techniques such as preparative HPLC, flash chromatography, or crystallization. These methods involve separating the impurities from the main product based on their chemical properties and physical characteristics.

Liraglutide impurities should be stored at recommended temperature conditions, typically 2-8°C or -20°C, depending on their stability. Improper storage can lead to degradation and loss of purity, so it's important to follow the manufacturer's instructions.

Liraglutide impurities can affect drug efficacy and safety. It is observed that impurities can cause adverse effects such as allergic reactions, injection site reactions, gastrointestinal disturbances, pancreatitis, or liver damage due to their toxicity or carcinogenic nature. Identifying and quantifying the impurities is essential during drug development.

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

Back to Top
Product has been added to your cart