Sparfloxacin

General Information

Sparfloxacin Impurities and Sparfloxacin

Daicel Pharma offers a comprehensive range of exclusive Sparfloxacin impurities such as Sparfloxacin Benzyl amino Impurity, Sparfloxacin de-amino Impurity, Sparfloxacin De-cyclopropyl Impurity, Sparfloxacin Fluoro Impurity, Sparfloxacin Hydroxy Impurity, and Sparfloxacin Diamino Impurity. These impurities are critical in determining the active pharmaceutical ingredient Sparfloxacin’s quality, stability, and biological safety. Additionally, Daicel Pharma can synthesize Sparfloxacin impurities according to precise customer specifications while guaranteeing worldwide delivery.

Sparfloxacin [CAS: 110871-86-8] is an antibacterial that treats various bacterial infections, such as pneumonia.

Sparfloxacin: Use and Commercial Availability  

Sparfloxacin is a fluoroquinolone antibiotic that treats bacterial infections. It treats various respiratory tract infections, including acute exacerbations of chronic bronchitis and community-acquired pneumonia caused by susceptible strains of microorganisms.

Sparfloxacin is available under Zagam, which effectively contains the active ingredient, Sparfloxacin.

Sparfloxacin Structure and Mechanism of Action

The chemical name of Sparfloxacin is rel-5-Amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid. Its chemical formula is C₁₉H₂₂F₂N₄O₃, and its molecular weight is approximately 392.4 g/mol.

Sparfloxacin functions by inhibiting the activity of bacterial enzymes, topoisomerase II (DNA-gyrase) and topoisomerase IV, involved in bacterial DNA replication, transcription, and repair.

Sparfloxacin Impurities and Synthesis

Impurities can arise during the synthesis¹ and storage of Sparfloxacin, including related substances, degradation products, or residual solvents. These impurities need monitoring and control to ensure the medication’s safety, efficacy, and quality.

Daicel offers a Certificate of Analysis (CoA) from a cGMP-compliant analytical facility for Sparfloxacin impurity standards like Sparfloxacin Benzyl amino Impurity, Sparfloxacin de-amino Impurity, Sparfloxacin De-cyclopropyl Impurity, Sparfloxacin Fluoro Impurity, Sparfloxacin Hydroxy Impurity, and Sparfloxacin Diamino Impurity. The CoA includes complete characterization data, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity. We give additional characterization data, including 13C-DEPT, on request. Daicel Pharma specializes in synthesizing unknown impurities or degradation products of Sparfloxacin.