Retinoic Acid

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4-Oxo-9-Cis Retinoic acid

  • CAT Number DCTI-C-1873
  • CAS Number NA
  • Molecular Formula C20H26O3
  • Molecular Weight 314.43

4-Oxo-all-trans Retinoic Acid

  • CAT NUMBER DCTI-C-1297
  • CAS NUMBER 38030-57-8
  • MOLECULAR FORMULA C20H26O3
  • MOLECULAR WEIGHT 314.43

5,6-Epoxy-9-Cis-Retinoic Acid

  • CAT Number DCTI-C-1874
  • CAS Number NA
  • Molecular Formula C20H28O3
  • Molecular Weight 316.44

All-trans 5,6-Epoxy Retinoic Acid

  • CAT NUMBER DCTI-C-2159
  • CAS NUMBER 13100-69-1
  • MOLECULAR FORMULA C20H28O3
  • MOLECULAR WEIGHT 316.42

Ethyl retinoate

  • CAT NUMBER DCTI-C-3029
  • CAS NUMBER 3899-20-5
  • MOLECULAR FORMULA C22H32O2
  • MOLECULAR WEIGHT 328.5

General Information

Retinoic Acid Impurities and Retinoic Acid

Daicel Pharma offers synthesis for Retinoic Acid impurity standards, which include 4-Oxo-9-Cis Retinoic acid, 5,6-Epoxy-9-Cis-Retinoic Acid, and All-trans 5,6-Epoxy Retinoic Acid. The quality, effectiveness, safety, and stability analysis of Retinoic Acid involves the use of these impurity standards.. Daicel Pharma offers custom Retinoic Acid impurities synthesis and delivers them worldwide.

Retinoic Acid [CAS: 302-79-4] is a naturally occurring derivative of retinol, Vitamin A. It is an all-trans-retinoate conjugate acid.

Retinoic Acid: Use and Commercial Availability 

Retinoic Acid is for the topical treatment of acne vulgaris, flat warts, and other skin conditions (psoriasis, ichthyosis congenita, ichthyosis vulgaris, lamellar icthyo, etc.). It helps in cell growth and early embryonic development. It also helps in cancer prevention and therapy.

This medication is available in the market under the brand names, Altreno, Avita, Retin-A, Refissa, and more.

Retinoic Acid Structure and Mechanism of Action Retinoic Acid Structure and Mechanism of Action

The chemical name of Retinoic Acid is (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. Its chemical formula is C20H28O2, and its molecular weight is approximately 300.4 g/mol.

The precise mechanism of action of Retinoic Acid is unknown.

Retinoic Acid Impurities and Synthesis

Impurities of Retinoic Acid are unintentional chemical compounds present during the manufacture or storage of retinoic acid, a vitamin A derivative frequently used in dermatology. They may form from raw materials, reagents, intermediates, or degradation products. Retinoic Acid impurities require strict control and monitoring to assure drug safety, efficacy, and quality, and analytical procedures help identify, quantify, and characterize these impurities.

Daicel Pharma provides a Certificate of Analysis (CoA) of Retinoic Acid impurity standards which include 4-Oxo-9-Cis Retinoic acid, 5,6-Epoxy-9-Cis-Retinoic Acid, and All-trans 5,6-Epoxy Retinoic Acid. Our cGMP-certified analytical facility provides a comprehensive CoA with detailed characterization data like 1H NMR, 13C NMR, IR, MASS, and HPLC purity. Additional characterizations like 13C-DEPT are available upon request.

References
FAQ's

Frequently Asked Questions

The acceptable limits for Retinoic Acid impurities defined by regulatory authorities or pharmacopeial standards differ depending on the type of specific impurity and its potential impact on drug safety and efficacy.

Yes, the presence of Retinoic Acid impurities can be minimized through careful control and monitoring during the manufacturing process and by implementing purification techniques.

The regulatory guideline for Retinoic acid impurities is determined by various regulatory authorities, which provide recommendations and their limits in pharmaceutical substances.

Retinoic Acid impurities should be stored at a controlled room temperature between 2-8°C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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