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Regadenoson Carboxylic Acid impurity

  • CAT Number DCTI-C-1635
  • CAS Number 313348-29-7
  • Molecular Formula C14H15N7O6
  • Molecular Weight 377.32
Regadenoson impurity C
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Regadenoson impurity C

  • CAT Number DCTI-C-1421
  • CAS Number 2015222-31-6
  • Molecular Formula C15H18N8O5
  • Molecular Weight 390.36

Regadenoson Impurity-2

  • CAT Number DCTI-C-829
  • CAS Number 313348-31-1
  • Molecular Formula C16H20N8O5
  • Molecular Weight 404.39

Regadenoson Impurity-7

  • CAT Number DCTI-C-828
  • CAS Number 37622-90-5
  • Molecular Formula C6H8N2O2
  • Molecular Weight 140.14

Regadenoson Impurity-A

  • CAS NUMBER 13364-95-9

Regadenoson Impurity-D

  • CAT Number DCTI-C-1629
  • CAS Number 313348-16-2
  • Molecular Formula C16H19N7O6
  • Molecular Weight 405.37

General Information

Regadenoson Impurities and Regadenoson 

Daicel Pharma synthesizes Regadenoson impurity standards such as Regadenoson Impurity-7, Regadenoson Impurity-2, Regadenoson impurity C, Regadenoson impurity A, Regadenoson impurity D, and Regadenoson Carboxylic Acid impurity. These impurities are essential for Regadenoson quality, effectiveness, safety, and stability. Furthermore, Daicel Pharma synthesizes custom Regadenoson impurities and delivers them globally.

Regadenoson [CAS: 313348-27-5] is an adenosine receptor agonist. It helps in coronary vasodilation and myocardial perfusion imaging.

Regadenoson: Use and Commercial Availability 

Regadenoson anhydrous is a Cardiac Stress Test Agent in Pharmacology. It is for diagnostic purposes. Rapiscan contains the active substance, Regadenoson, a selective coronary vasodilator. It is a stress agent for radionuclide myocardial perfusion imaging (MPI) for adult patients unable to undergo appropriate exercise stress. This drug is available under the tradename of Lexiscan.

Regadenoson Structure and Mechanism of Action Regadenoson Structure and Mechanism of Action

The chemical name of Regadenoson is 2-[4-[(Methylamino)carbonyl]-1H-pyrazol-1-yl]adenosine. Its chemical formula is C15H18N8O5, and its molecular weight is approximately 390.35 g/mol.

Regadenoson activates the A2A adenosine receptor, causes coronary vasodilation, and raises coronary blood flow (CBF).

Regadenoson Impurities and Synthesis

Regadenoson impurities are chemical compounds that form unintentionally during the production1 or storage of Regadenoson, a medicine used for cardiac stress testing. These impurities might come from raw materials, reagents, intermediates, or degradation products. Regadenoson impurities require strict control and monitoring to assure drug safety, efficacy, and quality, and analytical procedures help identify, quantify, and characterize these impurities.

Daicel Pharma offers a Certificate of Analysis (CoA) for Regadenoson impurity standards Regadenoson impurities such as Regadenoson Impurity-7, Regadenoson Impurity-2, Regadenoson impurity C, Regadenoson impurity A, Regadenoson impurity D, and Regadenoson Carboxylic Acid impurity. Our cGMP-certified analytical laboratory provides Daicel Pharma’s CoA and includes detailed characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. More characterization details, such as those for 13C-DEPT, can be provided on request. Daicel Pharma specializes in synthesizing Regadenoson impurities and degradation compounds.


Frequently Asked Questions

The impact of Regadenoson impurities on bioavailability can vary and may affect the drug's absorption, distribution, metabolism, and excretion, potentially altering its therapeutic efficacy and safety.

Yes, Regadenoson impurities can potentially lead to variability in its therapeutic effects.

The potential sources of impurities in Regadenoson synthesis can include starting materials, reagents, intermediates, and degradation products.

Regadenoson impurities should be stored at a controlled room temperature between 2-8°C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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