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Propiomazine-D6 Hydrochloride

  • CAT Number DCTI-A-214
  • CAS Number 2714474-32-3 (Free Base)
  • Molecular Formula C20H19D6ClN2OS (HCl Salt) C20H18D6N2OS (Free base)
  • Molecular Weight 382.98 (HCl Salt) 346.5 (Free base)

R-Propiomazine-D6 Hydrochloride

  • CAT Number DCTI-A-215
  • CAS Number NA
  • Molecular Formula C20H19D6ClN2OS (HCl Salt) C20H18D6N2OS (Free base)
  • Molecular Weight 382.98 (HCl Salt) 346.5 (Free base)

S-Propiomazine-D6 Hydrochloride

  • CAT Number DCTI-A-216
  • CAS Number NA
  • Molecular Formula C20H19D6ClN2OS (HCl Salt) C20H18D6N2OS (Free base)
  • Molecular Weight 382.98 (HCl Salt) 346.5 (Free base)

General Information

Propiomazine Impurities and Propiomazine  

Daicel Pharma synthesizes high-graded Propiomazine impurity standards. Their presence impacts the drug’s stability and causes potential adverse effects. Daicel Pharma offers a customized synthesis of Propiomazine impurities to cater to individual client requirements, with worldwide delivery options available.

Propiomazine [CAS: 362-29-8] belongs to the phenothiazine family of compounds, specifically a 10H-phenothiazine derivative. Propiomazine treats schizophrenia symptoms, agitation, and sedative.

Propiomazine: Use and Commercial Availability

Propiomazine treats insomnia due to its antihistamine-induced sleep-indulging properties. Propiomazine is a phenothiazine and an atypical antipsychotic. It has antihistamine properties and is a sedative in treating insomnia. This drug is available under the tradenames of Propavan, Largon, etc.

Propiomazine Structure and Mechanism of ActionPropiomazine Structure and Mechanism of Action 

The chemical name of Propiomazine is 1-[10-[2-(Dimethylamino)propyl]-10H-phenothiazin-2-yl]-1-propanone. Its chemical formula is C20H24N2OS, and its molecular weight is approximately 340.5 g/mol.

Propiomazine is an antagonist of dopamine receptors 1,2,3 and 4.

Propiomazine Impurities and Synthesis

The production1 and storage of Propiomazine can lead to the formation of impurities, which can affect its purity and effectiveness. It ensures the purity of the initial components and carefully controls the reaction conditions during the synthetic process to minimize impurity formation. Impurities in Propiomazine can arise from side reactions, incomplete reactions, or contaminants in the starting materials.

Daicel Pharma provides a Certificate of Analysis (CoA) for Propiomazine impurity standards. Our analytical laboratory that meets cGMP requirements generates the Certificate of Analysis (CoA) with complete information, including extensive characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. Further characterization data, such as 13C-DEPT, can be supplied upon request. Our team of professionals at Daicel Pharma specializes in providing Propiomazine impurities and labeled compounds for analyzing the efficacy of generic Propiomazine. Additionally, Daicel Pharma offers Propiomazine-D6 Hydrochloride, R-Propiomazine-D6 Hydrochloride, and S-Propiomazine-D6 Hydrochloride, deuterium-labeled Propiomazine compounds, crucial for bio-analytical research, including BA/BE investigations. Every delivery comes with a detailed characterization report.


Frequently Asked Questions

Yes, if the levels of Propiomazine impurities exceed regulatory limits or if they pose significant health risks, it can lead to batch rejection or recall of the product.

The solvent commonly used to analyze Propiomazine impurities is a mixture of water and organic solvents, such as methanol or acetonitrile.

Propiomazine impurities can alter the drug's bioavailability by affecting its absorption, distribution, metabolism, or excretion processes.

Propiomazine impurities are stored preferably at a regulated room temperature of 2-8°C or as specified on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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