Isoprenaline

General Information

Isoprenaline Impurities and Isoprenaline

Daicel Pharma offers the best quality Isoprenaline impurities, such as 2-chloro-1-(2,4-dihydroxyphenyl)ethan-1-one, 2-chloro-1-(4-hydroxyphenyl)ethan-1-one, Isoprenaline Impurity 3, and Isoprenaline Impurity 4. It is vital for evaluating the quality, stability, and biological safety of Isoprenaline. In addition, Daicel Pharma specializes in the custom synthesis of Isoprenaline impurities and ensures their worldwide delivery.

Isoprenaline [CAS: 7683-59-2] or Isoproterenol treats bradycardia conditions. It is a beta-1 adrenergic receptor agonist and beta-2 adrenergic receptor agonist. Isoprenaline has a structural resemblance to epinephrine. In addition, it has approval for treating cardiac arrest from heart block. It can treat asthma and has broncho-dilating effects.

Isoprenaline: Use and Commercial Availability

Isoprenaline administration is through intravenous means or infusion pumps. It has approval for heart blocks that don’t require pacing. It also treats Adams-Stokes syndrome. Further, it treats asthma, bronchospasm during anesthesia, cardiogenic shock, Electrical storm in patients with Brugada syndrome, etc. Isoprenaline is available under many brands globally. Some of the brands include Asthpul, Iludrin, Neodrenal, etc.

Isoprenaline Structure and Mechanism of Action

The chemical name of Isoprenaline is 4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]-1,2-benzenediol. The chemical formula for Isoprenaline is C₁₁H₁₇NO₃, and its molecular weight is approximately 211.26 g/mol.

Isoprenaline relaxes bronchial, uterine, and gastrointestinal smooth muscles. As beta-1 and beta-2 adrenergic receptor agonists, Isoprenaline inactivates myosin light chain kinase (MLCK), thus leading to bronchial dilation, smooth muscle relaxation, and peripheral vasodilation.

Isoprenaline Impurities and Synthesis

Impurities may occur during the synthesis of Isoprenaline ¹ that affect drug safety and efficacy. They form during the synthesis, storage, or degradation of Isoprenaline. It is necessary to control and monitor the impurities of Isoprenaline to improve the drug safety, efficacy, and storage.

Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Isoprenaline impurities, which includes 2-chloro-1-(2,4-dihydroxyphenyl)ethan-1-one, 2-chloro-1-(4-hydroxyphenyl)ethan-1-one, Isoprenaline Impurity 3, and Isoprenaline Impurity 4. The CoA is from a cGMP-compliant analytical facility. It contains the complete characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity². We give additional data like 13C-DEPT and CHN on request. Daicel Pharma can prepare any unidentified Isoprenaline impurity or degradation product. In addition, Daicel Pharma offers highly purified isotope-labeled standards of Isoprenaline for bioanalytical research and BA/BE studies for generic drugs. We also provide a complete characterization report on delivery.