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Cis Isomer of MCI-Glimepiride

  • CAT Number DCTI-C-757
  • CAS Number 32175-01-2
  • Molecular Formula C8H13NO
  • Molecular Weight 139.2

Cyclohexyl carboxyl glimepiride

  • CAT Number DCTI-C-1480
  • CAS Number 1217739-04-2
  • Molecular Formula C24H32N4O7S
  • Molecular Weight 520.6

Glimepiride Related Compound C

  • CAS NUMBER 119018-30-3

Trans-hydroxy Glimepiride

  • CAT Number DCTI-C-1199
  • CAS Number 600177-94-4
  • Molecular Formula C24H34N4O6S
  • Molecular Weight 506.62

General Information

Glimepiride Impurities and Glimepiride

Daicel Pharma offers worldwide delivery options for a custom synthesis of Glimepiride impurities, including impurities such as Cis Isomer of MCI-Glimepiride, Cyclohexyl carboxyl Glimepiride, and Trans-hydroxy Glimepiride. These impurities play a vital role in evaluating the purity and safety of Glimepiride, an active pharmaceutical ingredient.

Glimepiride [CAS: 93479-97-1] is a long-acting third-generation sulfonylurea medication. It lowers blood sugar levels and stimulates the secretion of insulin. With its extended duration of action and hypoglycemic effects, Glimepiride is an effective option for managing diabetes.

Glimepiride: Use and Commercial Availability  

Approved by the FDA for treating type 2 diabetes mellitus, Glimepiride is a second-generation sulfonylurea medication. It enhances glycemic control in adults. Glimepiride is used in cases where metformin is not tolerated. Amaryl is the brand name under which Glimepiride is available.

Glimepiride Structure and Mechanism of Action Glimepiride Structure and Mechanism of Action 

The chemical name of Glimepiride is 3-ethyl-4-methyl-N-(4-(N-((4-methylcyclohexyl)carbamoyl)sulfamoyl)phenethyl)-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide. Its chemical formula is C24H34N4O5S, and its molecular weight is approximately 490.6 g/mol.

Glimepiride stimulates the release of insulin from functioning pancreatic cells.

Glimepiride Impurities and Synthesis

Glimepiride impurities can form during synthesis1, storage, or usage, resulting from various factors such as side reactions and degradation. Analytical methods like HPLC, LC-MS, NMR, and IR help analyze and quantify these impurities. Control measures include optimizing synthetic conditions, purification steps, and implementing advanced analytical technology. Proper storage conditions and packaging are essential to minimize impurity formation during storage. Stability studies help assess impurity profiles over time. Compliance with regulatory guidelines ensures the quality and safety of Glimepiride.

Daicel Pharma strictly adheres to cGMP standards and operates an analytical facility for synthesizing Glimepiride impurity standards. We provide a range of Glimepiride impurities, such as Cis Isomer of MCI-Glimepiride, Cyclohexyl carboxyl glimepiride, and Trans-hydroxy Glimepiride. Our impurity standards have a detailed Certificate of Analysis (CoA) and a comprehensive characterization report. The CoA encompasses data obtained through techniques, including 1H NMR, 13C NMR, IR, MASS, and HPLC purity analysis2. We give additional data, such as 13C-DEPT, on request. We can synthesize unknown Glimepiride impurities or degradation products. Each delivery has a comprehensive characterization report.


Frequently Asked Questions

Yes, impurities in Glimepiride are routinely monitored during stability studies to assess the long-term quality and safety of the drug.

Impurities in Glimepiride are identified by comparing their chromatographic or spectral characteristics with those of known impurities or reference standards.

Manufacturers strive to minimize impurities during synthesis, and purification techniques can be employed to reduce impurity levels.

The recommendation is to store Glimepiride impurities at a controlled room temperature, within 2-8 °C.

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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