Atenolol

General Information

Atenolol Impurities and Atenolol

Daicel Pharma offers superior-quality Atenolol impurities, such as N-Nitroso Atenolol Impurity. It is vital to evaluate Atenolol quality, stability, and biological safety. In addition, Daicel Pharma specializes in the custom synthesis of atenolol impurities and ensures their worldwide delivery.
Atenolol [CAS: 29122-68-7] is an ethanolamine derivative and is an antihypertensive medicine. It is a synthetic, second-generation, beta1-selective adrenoreceptor blocking agent. It helps lower blood pressure and myocardial contractility in patients.

Atenolol: Use and Commercial Availability  

As an adrenergic beta-blocker, Atenolol reduces the risk of cardiovascular disease in patients. It is a US FDA-approved drug for treating angina pectoris, hypertension, and myocardial infarction. It is used alone as a monotherapy or combined with other antihypertensive drugs. Further, it can treat arrhythmias and prevent migraines. It can also manage supraventricular tachycardia, atrial fibrillation, and alcohol withdrawal in patients. Various generic manufacturers prepare Atenolol. It is available orally under brands such as Tenormin, Prenormine, Atenil, Betacard, etc.

Atenolol Structure and Mechanism of Action

The chemical name of Atenolol is 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide. The chemical formula for Atenolol is C₁₄H₂₂N₂O₃, and its molecular weight is approximately 266.34 g/mol.

Atenolol binds selectively to the beta-1 adrenergic receptors in the heart and vascular smooth muscles. It inhibits sympathetic stimulation, causing a decrease in heart rate and blood pressure.

Atenolol Impurities and Synthesis

While synthesizing Atenolol1, impurities may form that will affect the safety and efficacy of the drug. These impurities form during Atenolol synthesis, purification, storage, or degradation. Controlling and monitoring Atenolol impurities improves the drug’s safety, efficacy, and storage.
Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Atenolol impurities, which includes N-Nitroso Atenolol Impurity. A CoA is from a cGMP-compliant analytical facility. It contains the complete characterization data2 such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity3. We give additional spectral data on request. Daicel Pharma can prepare any unidentified Atenolol impurity or degradation product. In addition, Daicel Pharma offers a highly purified, stable deuterium-labeled standard of N-Nitroso Atenolol-d5. A complete characterization report is available on delivery.