Vortioxetine Impurities and Vortioxetine
Daicel Pharma is a reliable supplier of high-quality impurity standards for Vortioxetine, which includes Vortioxetine N-Formyl Impurity and Vortioxetine N-Methyl Impurity. These impurities are critical in thoroughly assessing the quality, stability, and safety of the active pharmaceutical ingredient, Vortioxetine. Moreover, Daicel Pharma provides Vortioxetine impurities to meet client requirements with utmost precision. With worldwide shipping capabilities, customers can conveniently receive these impurities anywhere, ensuring unparalleled convenience.
Vortioxetine [CAS: 508233-74-7] is a serotonergic antidepressant of a class of drugs known as serotonin modulators. It treats MDD (Major Depressive Disorder) in adults.
Vortioxetine: Use and Commercial Availability
Vortioxetine is a medication used to treat major depressive disorder (MDD) in adults. It affects the neurotransmitter levels in the brain. It can help alleviate the symptoms of depression, such as persistent sadness, loss of interest, changes in appetite or sleep patterns, and lack of energy. Vortioxetine is available under the brand name, Brintellix, which contains the active ingredient, Vortioxetine.
Vortioxetine Structure and Mechanism of Action
The chemical name of Vortioxetine is 1-[2-[(2,4-Dimethylphenyl)thio]phenyl]piperazine. Its chemical formula is C18H22N2S, and its molecular weight is approximately 298.4 g/mol.
Vortioxetine enhances serotonergic activity in the CNS by inhibiting serotonin reuptake.
Vortioxetine Impurities and Synthesis
Vortioxetine impurities can arise during synthesis1 due to the storage or use of specific raw materials and intermediates in manufacturing. These impurities encompass related compounds, degradation products, and process impurities. Stringent quality control measures and analytical methods are crucial to ensure the purity and safety of Vortioxetine for patient use.
Daicel Pharma provides a comprehensive Certificate of Analysis (CoA) for Vortioxetine impurity standards, such as Vortioxetine N-Formyl Impurity and Vortioxetine N-Methyl Impurity. The CoA includes detailed characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. Additionally, upon delivery, we give 13C-DEPT. Daicel possesses the technology and expertise to synthesize any unknown Vortioxetine impurity or degradation product. We also offer labeled compounds to quantify the efficacy of generic Vortioxetine. For bioanalytical research and BA/BE studies, Daicel also supplies Vortioxetine-D8, a deuterium-labeled Vortioxetine compound.
- Ruhland, Thomas; Smith, Garrick Paul; Bang-Andersen, Benny; Pueschl, Ask; Moltzen, Ejner Knud; Andersen, Kim, Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors, H. Lundbeck A/S, Denmark, WO2003029232A1, April 10, 2003
- Atila Karaca, Sakine; Rashidova, Nurana; Ugur, Alper; Yeniceli Ugur, Duygu, Development of a simple HPLC method for the quantitation of vortioxetine in pharmaceuticals using DoE approach, Chemical Papers, Volume: 74, Issue: 5, Pages: 1541-1549, 2020
Frequently Asked Questions
Impurities in Vortioxetine are significant as they can affect the medication's quality, efficacy, and safety. Their presence may alter the drug's characteristics. Therefore, it is crucial to identify and monitor impurities to ensure the product's quality and patient safety.
Some providers specialize in customizing Vortioxetine impurities to meet client specifications.
Yes, certain impurities in Vortioxetine can potentially pose risks to patients and is essential to detect them.
Vortioxetine impurities are identified and characterized using advanced analytical techniques such as mass spectrometry (MS).
The recommendation is to store Vortioxetine impurities at room temperature, within 2-8 °C.
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