Verapamil Impurities and Verapamil
Daicel Pharma is a trusted provider of quality Verapamil impurity standards including, 2-(3,4-dimethoxyphenyl)-2-isopropyl-5-oxopentanenitrile, 2-(3,4-dimethoxyphenyl)-5-((4-hydroxy-3-methoxyphenethyl)(methyl)amino)-2-isopropylpentanenitrile, 2-chloro-N-(3,4-dimethoxyphenethyl)-N-methylethan-1-amine, 3-bromo-N-(3,4-dimethoxyphenethyl)-N-methylpropan-1-amine and many more.
These impurities are crucial in meticulously evaluating the quality, stability, and safety of the active pharmaceutical ingredient, Verapamil. Furthermore, Daicel Pharma customizes Verapamil impurity standards, guaranteeing to meet individual client specifications. With global shipping capabilities, these impurities can be conveniently delivered to customers worldwide, offering unparalleled convenience.
Verapamil [CAS: 52-53-9] is a first-generation calcium channel blocker and treats hypertension, angina pectoris, and supraventricular tachyarrhythmias.
Verapamil: Use and Commercial Availability
Verapamil treats various cardiovascular conditions. It is for vasospastic (Prinzmetal’s) angina, unstable, and chronic stable angina. It effectively relaxes and widens blood vessels, reduces the workload on the heart, and helps regulate heart rhythm. Verapamil plays a vital role in controlling blood pressure, alleviating chest pain, and managing abnormal heart rhythms, ultimately improving the overall cardiovascular health of patients. Verapamil is available under the brand names Calan, Calan SR, Covera-HS, Verelan, Verelan PM and Isoptin.
Verapamil Structure and Mechanism of Action
The chemical name of Verapamil is α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile. Its molecular formula is C27H38N2O4, and its molecular weight is approximately 454.6 g/mol.
Verapamil selectively blocks the transmembrane influx of calcium ions into arterial smooth muscle cells and myocardial cells.
Verapamil Impurities and Synthesis
Verapamil impurities can arise during synthesis1 due to the storage or use of specific raw materials and intermediates in manufacturing. These impurities encompass related compounds, degradation products, and process impurities. Stringent quality control measures and analytical methods are crucial to ensure the purity and safety of Verapamil for patient use.
Daicel provides a comprehensive Certificate of Analysis (CoA) for Verapamil impurity standards, such as 2-(3,4-dimethoxyphenyl)-2-isopropyl-5-oxopentanenitrile, 2-(3,4-dimethoxyphenyl)-5-((4-hydroxy-3-methoxyphenethyl)(methyl)amino)-2-isopropylpentanenitrile, 2-chloro-N-(3,4-dimethoxyphenethyl)-N-methylethan-1-amine, 3-bromo-N-(3,4-dimethoxyphenethyl)-N-methylpropan-1-amine and many more.
The CoA includes detailed characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. Additionally, upon delivery, 13C-DEPT is also provided. Daicel possesses the technology and expertise to synthesize any unknown Verapamil impurity or degradation product. We also offer labeled compounds to quantify the efficacy of generic Verapamil. For bioanalytical research and BA/BE studies, Daicel supplies highly pure Nor-Verapamil D6 HCl, R-Nor Verapamil-D6. HCl, R-Verapamil-D6. HCl, S-Verapamil.HCl-D6, S-Nor Verapamil.HCl-D6, Verapamil D6.HCl, deuterium-labeled impurity standards of Verapamil.
- Basically substituted phenyl acetonitrile compounds, Knoll Akt.-Ges. Chemische Fabriken, Germany, US3261859A, July 19, 1966
- Harapat, Sandra R.; Kates, Robert E., Rapid high-pressure liquid chromatographic analysis of verapamil in blood and plasma, Journal of Chromatography, Volume: 170, Issue: 2, Pages: 385-90, 1979
Frequently Asked Questions
Reverse-phase Ultra-performance liquid chromatography (RP-UPLC) is employed to separate and analyze the impurities of Verapamil.
Regulating impurities in Verapamil is crucial to maintain the drug's safety, effectiveness, and quality. They can impact the drug's potency, stability, and how it is absorbed in the body, potentially leading to adverse effects and reduced therapeutic outcomes.
Impurities in Verapamil can form during manufacturing, storage, and transportation. They can originate from starting materials, intermediates, or by-products of chemical reactions.
Impurities found in Verapamil can be classified into several categories, which include process-related contaminants, degradation products, residual solvents, and genotoxic impurities.
The recommendation is to store Verapamil impurities at room temperature, within 2-8 °C.
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