Varenicline

Sort by

(1R,5S)-8-nitro-2,3,4,5-tetrahydro-1H-1,5-methanob...

  • CAT NUMBER DCTI-C-2566
  • CAS NUMBER NA
  • MOLECULAR FORMULA C13H12F3N3O3
  • MOLECULAR WEIGHT 219.24

1-((1R,5S)-8-amino-6-nitro-1,2,4,5-tetrahydro-3H-1...

  • CAT NUMBER DCTI-C-2683
  • CAS NUMBER NA
  • MOLECULAR FORMULA C13H12F3N3O3
  • MOLECULAR WEIGHT 315.25

1-((1R,5S)-8-amino-6-nitro-1,2,4,5-tetrahydro-3H-1...

  • CAT NUMBER DCTI-C-2562
  • CAS NUMBER NA
  • MOLECULAR FORMULA C13H12F3N3O3
  • MOLECULAR WEIGHT 315.25

Depyrazine 7,8-Dinitrophenyl Varenicline

  • CAT NUMBER DCTI-C-2638
  • CAS NUMBER 230615-08-4
  • MOLECULAR FORMULA C11H11N3O
  • MOLECULAR WEIGHT 249.23

Methyl Varenicline Impurity

  • CAT NUMBER DCTI-C-2577
  • CAS NUMBER 1333145-89-3
  • MOLECULAR FORMULA C14H15N3 (Free base)
  • MOLECULAR WEIGHT 225.30 (Free base)

N-Nitroso Varenicline

  • CAT NUMBER DCTI-C-2488
  • CAS NUMBER 2755871-02-2
  • MOLECULAR FORMULA C13H12N4O
  • MOLECULAR WEIGHT 240.27

Trifluoroacetyl Varenicline Hydroxymethyl Impurity

  • CAT NUMBER DCTI-C-2552
  • CAS NUMBER NA
  • MOLECULAR FORMULA C16H14F3N3O2
  • MOLECULAR WEIGHT 337.3

Varenicline impurity I

  • CAT NUMBER DCTI-C-2637
  • CAS NUMBER 230615-70-0
  • MOLECULAR FORMULA C15H12F3N3O
  • MOLECULAR WEIGHT 307.28

Varenicline Impurity II

  • CAT NUMBER DCTI-C-2640
  • CAS NUMBER 357424-12-5
  • MOLECULAR FORMULA C12H13N3
  • MOLECULAR WEIGHT 199.25
LOAD MORE
You're viewed 9 of 12 products

General Information

Varenicline Impurities and Varenicline 

Daicel Pharma is a reliable partner for synthesizing high-quality Varenicline impurities, specifically 1-((1R,5S)-8-amino-6-nitro-1,2,4,5-tetrahydro-3H-1,5-methanobenzo[d]azepin-3-yl)-2,2,2-trifluoroethan-1-one, Methyl Varenicline Impurity, N-Nitroso Varenicline, Varenicline Impurity II, Trifluoroacetyl Varenicline Hydroxymethyl Impurity, Varenicline tartrate adduct and more. These impurities help assess the quality, stability, and safety of the active pharmaceutical ingredient, Varenicline. Daicel Pharma also offers custom synthesis of Varenicline impurities, which can be shipped worldwide.

Varenicline [CAS: 249296-44-4] is a medication that acts as a partial agonist of the nicotinic acetylcholine receptor, alpha4beta2. It helps in giving up smoking.

Varenicline: Use and Commercial Availability  

Varenicline is an organic compound similar to cytisine that acts as a partial agonist for nicotinic cholinergic receptors. It is available in its tartrate salt form. Varenicline helps as a smoking cessation aid, with patients undergoing education and counseling in conjunction with its use. It is considered the first line of treatment for smoking cessation due to its ability to prevent short-term and long-term relapse. Varenicline appears more effective than bupropion and equally effective as nicotine replacement therapy. Additionally, Varenicline has a lower risk of withdrawal symptoms due to its partial agonist properties. Some of the brand names for Varenicline include Chantix and Tyrvaya.

Varenicline Structure and Mechanism of Action Varenicline Structure and Mechanism of Action

The chemical name of Varenicline is 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine. Its chemical formula is C13H13N3, and its molecular weight is approximately 211.26 g/mol.

Varenicline binds selectively and with affinity at α4β2 neuronal nicotinic acetylcholine receptors. It ends smoking in patients and prevents nicotine binding at α4β2 receptors.

Varenicline Impurities and Synthesis

During the synthesis1 and storage of Varenicline, impurities may form that can affect the drug’s safety and efficacy. Some impurities include related substances, starting materials, and degradation products. The impurity control is through proper process development, purification, and storage conditions.

Daicel Pharma issues a Certificate of Analysis (CoA) for Varenicline impurity standards, including 1-((1R,5S)-8-amino-6-nitro-1,2,4,5-tetrahydro-3H-1,5-methanobenzo[d]azepin-3-yl)-2,2,2-trifluoroethan-1-one, Methyl Varenicline Impurity, N-Nitroso Varenicline, Varenicline Impurity II, Trifluoroacetyl Varenicline Hydroxymethyl Impurity, Varenicline tartrate adduct and more. The CoA is from an analytical facility that complies with current Good Manufacturing Practices (cGMP) and includes comprehensive characterization data, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. We give additional characterization data such as 13C-DEPT and CHN on request. Daicel Pharma can prepare unknown Varenicline impurities or degradation products. A complete characterization report accompanies each delivery.

References
FAQ's

Frequently Asked Questions

HPLC separates impurities based on their chemical and physical properties, such as molecular weight, polarity, and charge. The separated impurities are then detected using a UV detector or a mass spectrometer.

Mass spectrometry is a sensitive technique that can detect and quantify impurities in Varenicline at low levels. It provides information on the molecular weight and structure of the impurities that helps in their identification and characterization.

Methanol or Acetonitrile is a solvent used in analyzing many impurities in Varenicline.

Varenicline impurities are stored at a controlled room temperature between 2-8 ⁰C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

Back to Top
Product has been added to your cart