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Trametinib
References
FAQ's
References
- Sakai, Toshiyuki; Kawasaki, Hisashi; Abe, Hiroyuki; Hayakawa, Kazuhide; Iida, Tetsuya; Kikuchi, Shinichi; Yamaguchi, Takayuki; Nanayama, Toyomichi; Kurachi, Hironori; Tamaru, Masahiro; et al, 5-Amino-2,4,7-Trioxo-3,4,7,8-Tetrahydro-2h-Pyrido[2,3-D]Pyrimidine Derivatives And Related Compounds For The Treatment Of Cancer, Japan Tobacco Inc., Japan, EP1761528B1, January 9, 2008
- Madhuresh K. Sethi*, Sanjay Mahajan, Bhairaiah Mara, Upendranath Veera, Anitha Nimmagadda and Purbita Chakraborty, Identification and synthesis of impurities formed during Trametinib Dimethyl sulfoxide preparation, Der Pharmacia Lettre, 2016, 8 (6):321-327
- Nijenhuis, C. M.; Haverkate, H.; Rosing, H.; Schellens, J. H. M.; Beijnen, J. H., Simultaneous quantification of dabrafenib and trametinib in human plasma using high-performance liquid chromatography-tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis Volume: 125, Pages: 270-279, 2016
Frequently Asked Questions
How are Trametinib impurities detected and quantified?
Analytical Methods such as High-Performance Liquid Chromatography (HPLC) can detect impurities in Trametinib.
Can Trametinib impurities affect patient safety?
Yes, impurities in Trametinib can impact patient safety. Depending on their nature and concentration, contaminants can cause adverse effects or reduce the efficacy of the medication.
Which solvents help in the analysis of Trametinib impurities?
Methanol achieves optimal solubility and separation of Trametinib impurities.
What are the temperature conditions required to store Trametinib impurities?
Trametinib impurities should generally be stored at a controlled room temperature between 2-8 ⁰C or as indicated on the Certificate of Analysis (CoA).
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