Timolol

General Information

Timolol Impurities and Timolol 

Daicel Pharma is a trusted provider of vital Timolol impurities, including R-Timolol, Timolol Impurity-D, and Timolol Impurity-F. These impurities are crucial in assessing the quality, stability, and biological safety of the active pharmaceutical ingredient, Timolol. Moreover, Daicel Pharma excels in tailoring the synthesis of Timolol impurities to meet individual client specifications. With worldwide shipping facilities, customers can enjoy the convenience and flexibility of accessing these high-quality impurities.

Timolol [CAS: 26839-75-8] is a nonselective beta-adrenergic receptor blocker that treats and manages open-angle glaucoma and ocular hypertension.

Timolol: Use and Commercial Availability

Timolol treats various conditions such as ocular hypertension, angina pectoris, and the prevention of vascular headaches. It manages elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. It also prevents migraine headaches.

Timolol is available under Betimol, Blocadren, Istalol, etc., which contain the active ingredient, Timolol.

Timolol Structure and Mechanism of Action  

The chemical name of Timolol is (2S)-1-[(1,1-Dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol. Its chemical formula is C₁₃H₂₄N₄O₃S, and its molecular weight is approximately 316.42 g/mol.

The exact mechanism of action of Timolol is unknown.

Timolol Impurities and Synthesis 

In manufacturing¹ Timolol, impurity formation is possible, which impacts its effectiveness. They may originate from different sources, such as raw materials, intermediates, and chemicals for synthesizing Timolol. It is crucial to closely manage and monitor these impurities to safeguard the optimal efficacy and safety of the medication.

Daicel offers a wholesome and integrated Certificate of Analysis (CoA) for Timolol impurity standards, encompassing R-Timolol, Timolol Impurity-D, and Timolol Impurity-F. The CoA provides detailed characterization data, including 1H NMR, 13C NMR, IR, MASS, and HPLC purity². Additionally, we give a detailed 13C-DEPT upon delivery. With advanced technology and expertise, Daicel can synthesize any unknown Timolol impurity or degradation product. We also supply labeled compounds, facilitating the quantification of generic Timolol’s efficacy. For bioanalytical research and BA/BE studies, Daicel offers Timolol-D9 Maleate, deuterium-labeled Timolol impurity standards.