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3-Trifluoromethyl Teriflunomide

  • CAS NUMBER 63927-52-6

Pentanamide compound (teriflunomide)

  • CAS NUMBER 2734292-21-6

Teriflunomide imp-B

  • CAT Number DCTI-C-007
  • CAS Number NA
  • Molecular Formula C12H12N2O3
  • Molecular Weight 232.24

Teriflunomide Impurity

  • CAT Number DCTI-C-132
  • CAS Number 2809442-03-1
  • Molecular Formula C10H7F3N2O2
  • Molecular Weight 244.17

General Information

Teriflunomide Impurities and Teriflunomide 

Daicel Pharma offers optimal Teriflunomide impurities such as 3-Trifluoromethyl Teriflunomide, Pentanamide compound (teriflunomide), Teriflunomide imp-B and Teriflunomide Impurity They help analyze the quality, stability, and biological safety of the active pharmaceutical ingredient, Teriflunomide. Daicel Pharma can synthesize Teriflunomide impurities and ensure global delivery to customer requirements.

Teriflunomide [CAS: 163451-81-8] is a novel disease-modifying agent indicated for treating multiple sclerosis (MS). It is a tyrosine kinase inhibitor and a non-steroidal anti-inflammatory drug.

Teriflunomide: Use and Commercial Availability  

Teriflunomide manages relapsing forms of multiple sclerosis (MS) and rheumatoid arthritis. It is an active metabolite of Leflunomide, an immunosuppressant.

This medicine is available under Aubagio, which contains the active ingredient Teriflunomide.

Teriflunomide Structure and Mechanism of ActionTeriflunomide Structure and Mechanism of Action

The chemical name of Teriflunomide is (2Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide. Its chemical formula is C12H9F3N2O2, and its molecular weight is approximately 270.21 g/mol.

Teriflunomide may reduce the number of activated lymphocytes in the CNS, but its exact mechanism of action is unknown.

Teriflunomide Impurities and Synthesis

Teriflunomide impurities form during synthesis1 and vary depending on the synthetic route and the reaction conditions. Vigilant monitoring and regulation of impurity formation are essential, as these impurities can affect the drug’s efficacy.

Daicel Pharma offers a Certificate of Analysis (CoA) from a cGMP-compliant analytical facility for Teriflunomide impurity standards like 3-Trifluoromethyl Teriflunomide, Pentanamide compound (teriflunomide), Teriflunomide imp-B and Teriflunomide Impurity. The CoA includes complete characterization data, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. We give additional characterization data, including 13C-DEPT, on request. Daicel Pharma can synthesize unknown impurities or degradation products of Teriflunomide.


Frequently Asked Questions

Analytical methods like LC-MS/MS can detect and quantify impurities in Teriflunomide.

Impurities in Teriflunomide can impact patient safety. Depending on their nature and concentration, contaminants can cause adverse effects or reduce the efficacy of the medication.

Methanol helps to enhance the solubility of Teriflunomide impurities

Teriflunomide impurities are stored at a controlled room temperature between 2-8 ⁰C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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