Pridinol
General Information
Pridinol Impurities and Pridinol
Daicel Pharma offers superior-quality Pridinol impurities, such as Pridinol impurity B. It is vital for evaluating Pridinol quality, stability, and biological safety. In addition, Daicel Pharma specializes in the custom synthesis of Pridinol impurities and ensures their worldwide delivery.
Pridinol [CAS: 511-45-5] is a 1-substituted piperidine derivative. It is a medicine for treating Parkinson’s disease. In addition, Pridinol relaxes the muscles of patients suffering from severe muscle pain. As an anticholinergic agent, Pridinol stops involuntary muscle movements.
Pridinol: Use and Commercial Availability
Pridinol is a drug used in the treatment of Parkinson’s disease. Pridinol helps in the treatment of skeletal muscle hyperactivity. It also acts as an adjuvant to anesthetics. Further, it helps treat adult patients suffering from lumbalgia, torticollis, and general muscle pain. It is administered orally or by intramuscular injection to patients. There are many generic manufacturers of Pridinol. It is available under Myopridin, Nonplesin, and more.
Pridinol Structure and Mechanism of Action
The chemical name of Pridinol is 1,1-Diphenyl-3-(piperidin-1-yl)propan-1-ol. The chemical formula for Pridinol is C20H25NO, and its molecular weight is approximately 295.42 g/mol.
Pridinol reduces polysynaptic reflexes by blocking acetylcholine receptors in the brain.
Pridinol Impurities and Synthesis
During the synthesis of Pridinol 1, impurities may form that may affect the safety and efficacy of the drug. These impurities form during the synthesis, storage, or degradation of Pridinol. As a result, Pridinol impurities must be controlled and monitored throughout the drug’s lifecycle.
Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Pridinol impurities, which includes Pridinol impurity B. The CoA is from a cGMP-compliant analytical facility and encompasses complete characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. We give additional data like 13C-DEPT and CHN on request. Daicel Pharma can prepare any unidentified Pridinol impurity or degradation product. In addition, Daicel Pharma offers highly purified deuterium-labeled standards of Pridinol-D5 for bioanalytical research and BA/BE studies. We also provide a complete characterization report on delivery.
References
FAQ's
References
- Adamson, Donald W., Improvements in and relating to the preparation of substituted γ-hydroxypropylamines, GB624118A, May 27, 1949, The Wellcome Foundation Ltd.
- Bianchini, Romina M.; Castellano, Patricia M.; Kaufman, Teodoro S., Validated stability-indicating HPLC method for the determination of pridinol mesylate. Kinetics study of its degradation in acid medium, Journal of Pharmaceutical and Biomedical Analysis, Volume: 48, Issue: 4, Pages: 1151-1160, 2008 DOI: (10.1016/j.jpba.2008.09.005)
Frequently Asked Questions
How do Pridinol impurities form in the drug product?
Unreacted starting materials, by-products, residual solvents, and degradation products form Pridinol impurities in the drug product.
Why is it vital to control Pridinol Impurities?
Controlling Pridinol Impurities is essential for the drug to be safe, effective, and stable.
How to avoid the formation of Pridinol Impurities in the drug substance?
Having process knowledge in controlling the number of catalysts, reagents, solvents, equipment selection, and using proper GMP controls helps avoid the formation of Pridinol Impurities in the drug substance.
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