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Phytonadione Impurities

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(2E)-1-chloro-3,7,11,15-tetramethylhexadec-2-ene

(2E)-1-chloro-3,7,11,15-tetramethylhexadec-2-ene

  • CAT Number DCTI-C-004076
  • CAS NUMBER 2580987-82-0
  • MOLECULAR FORMULA C20H39Cl
  • MOLECULAR WEIGHT 314.98
(2Z)-1-chloro-3,7,11,15-tetramethylhexadec-2-ene

(2Z)-1-chloro-3,7,11,15-tetramethylhexadec-2-ene

  • CAT Number DCTI-C-004075
  • CAS NUMBER 2580987-83-1
  • MOLECULAR FORMULA C20H39Cl
  • MOLECULAR WEIGHT 314.98
(E)-2-methyl-3-(3,7,11,15-tetramethylhexadeca-2,14-dien-1-yl)naphthalene-1,4-dione

(E)-2-methyl-3-(3,7,11,15-tetramethylhexadeca-2,14...

  • CAT Number DCTI-C-003201
  • CAS NUMBER NA
  • MOLECULAR FORMULA C31H44O2
  • MOLECULAR WEIGHT 448.69
1-(1,4-dihydroxynaphthalen-2-yl)ethan-1-one

1-(1,4-dihydroxynaphthalen-2-yl)ethan-1-one

  • CAT Number DCTI-C-003408
  • CAS NUMBER 40420-48-2
  • MOLECULAR FORMULA C12H10O3
  • MOLECULAR WEIGHT 202.21
DCTI-C-1803

1,4-Naphthalenediol, 2-methyl-, 1-acetate

  • CAT Number DCTI-C-001803
  • CAS Number NA
  • Molecular Formula C13H12O3
  • Molecular Weight 216.24
2-Acetyl-1,4-naphthoquinone

2-Acetyl-1,4-naphthoquinone

  • CAT Number DCTI-C-001871
  • CAS Number NA
  • Molecular Formula C12H8O3
  • Molecular Weight 200.19
2-Acetyl-3-methyl-1,4-naphthalenedione

2-Acetyl-3-methyl-1,4-naphthalenedione

  • CAT Number DCTI-C-001804
  • CAS Number NA
  • Molecular Formula C13H10O3
  • Molecular Weight 214.22
2-methyl-3-((2E,6E)-3,7,11,15-tetramethylhexadeca-2,6-dien-1-yl)naphthalene-1,4-dione

2-methyl-3-((2E,6E)-3,7,11,15-tetramethylhexadeca-...

  • CAT Number DCTI-C-003226
  • CAS NUMBER NA
  • MOLECULAR FORMULA C31H44O2
  • MOLECULAR WEIGHT 448.69
2-methylnaphthalene-1,4-diyl diacetate

2-methylnaphthalene-1,4-diyl diacetate

  • CAT Number DCTI-C-003409
  • CAS NUMBER  573-20-6
  • MOLECULAR FORMULA C15H14O4
  • MOLECULAR WEIGHT 258.27
2,3-Epoxide Vitamin K1 Isomer-I

2,3-Epoxide Vitamin K1 Isomer-I

  • CAT Number DCTI-C-001158
  • CAS Number NA
  • Molecular Formula C31H46O3
  • Molecular Weight 466.71
2,3-Epoxide Vitamin K1 Isomer-II

2,3-Epoxide Vitamin K1 Isomer-II

  • CAT Number DCTI-C-001159
  • CAS Number NA
  • Molecular Formula C31H46O3
  • Molecular Weight 466.71
Phytonadione-DCTI-A-010-Daicel

Cis-Phytonadione

  • CAT Number DCTI-A-000010
  • CAS Number 16033-41-3
  • Molecular Formula C31H46O2
  • Molecular Weight 450.71
Phytonadione-DCTI-A-011-Daicel

Cis-Phytonadione-D7

  • CAT Number DCTI-A-000011
  • CAS Number NA
  • Molecular Formula C31H39D7O2
  • Molecular Weight 457.75

Cyclopentadiene-Menadione Cyclo adduct

  • CAT Number DCTI-C-002071
  • CAS NUMBER 2457204-51-0
  • MOLECULAR FORMULA C16H14O2
  • MOLECULAR WEIGHT 238.29
Dihydro vitamin K1 / Phytonadione Dihydroxy Impurity

Dihydro vitamin K1 / Phytonadione Dihydroxy Impurity

  • CAT Number DCTI-C-000450
  • CAS Number 572-96-3
  • Molecular Formula C31H48O2
  • Molecular Weight 452.72

Menaquinone-4

  • CAT Number DCTI-C-003345
  • CAS NUMBER 863-61-6
  • MOLECULAR FORMULA C31H40O2
  • MOLECULAR WEIGHT 444.66
Naphthalene-1,4-diyl diacetate

Naphthalene-1,4-diyl diacetate

  • CAT Number DCTI-C-001862
  • CAS Number NA
  • Molecular Formula C14H12O4
  • Molecular Weight 244.25
Phthalic acid, Phytonadione Impurity

Phthalic acid, Phytonadione Impurity

  • CAT Number DCTI-C-001371
  • CAS Number 88-99-3
  • Molecular Formula C8H6O4
  • Molecular Weight 166.13
Phthiocol, Phytonadione Related Impurity

Phthiocol, Phytonadione Related Impurity

  • CAT Number DCTI-C-001370
  • CAS Number 483-55-6
  • Molecular Formula C11H8O3
  • Molecular Weight 188.18

Phytanadione specified unidentified Impurity

  • CAT Number DCTI-C-004199
  • CAS NUMBER NA
  • MOLECULAR FORMULA C31H48O5
  • MOLECULAR WEIGHT 500.72
Phytonadione-DCTI-C-421-Daicel

Phytonadione

  • CAT Number DCTI-C-000421
  • CAS Number 84-80-0
  • Molecular Formula C31H46O2
  • Molecular Weight 450.71
Phytonadione-DCTI-C-631-Daicel

Phytonadione (Mixture of Trans Racemic & Cis Racemic)

  • CAT Number DCTI-C-000631
  • CAS Number NA
  • Molecular Formula C31H46O2
  • Molecular Weight 450.71
Phytonadione Cis-I / Cis Phytonadione Diastereomer-1

Phytonadione Cis-I / Cis Phytonadione Diastereomer-1

  • CAT Number DCTI-C-000422
  • CAS Number NA
  • Molecular Formula C31H46O2
  • Molecular Weight 450.71
Phytonadione Cis-II / Cis Phytonadione Enantiomer

Phytonadione Cis-II / Cis Phytonadione Enantiomer

  • CAT Number DCTI-C-000423
  • CAS Number NA
  • Molecular Formula C31H46O2
  • Molecular Weight 450.71
Phytonadione Cis-III / Cis Phytonadione

Phytonadione Cis-III / Cis Phytonadione

  • CAT Number DCTI-C-000424
  • CAS Number NA
  • Molecular Formula C31H46O2
  • Molecular Weight 450.71
Cis Phytonadione Diastereomer-2

Phytonadione Cis-IV / Cis Phytonadione Diastereomer-2

  • CAT Number DCTI-C-000425
  • CAS Number NA
  • Molecular Formula C31H46O2
  • Molecular Weight 450.71
Phytonadione-DCTI-C-1376-Daicel

Phytonadione Di-Hydroxy Epoxide Impurity – Diastereomer-1

  • CAT Number DCTI-C-001376
  • CAS Number NA
  • Molecular Formula C31H48O5
  • Molecular Weight 500.72
Phytonadione-DCTI-C-1379-Daicel

Phytonadione Dihydroxy Epoxide Impurity – Diastereomer-2

  • CAT Number DCTI-C-001379
  • CAS Number NA
  • Molecular Formula C31H48O5
  • Molecular Weight 500.72
Phytonadione-DCTI-C-1380-Daicel

Phytonadione Dihydroxy Epoxide Impurity – Diastereomer-3

  • CAT Number DCTI-C-001380
  • CAS Number NA
  • Molecular Formula C31H48O5
  • Molecular Weight 500.72
Phytonadione-DCTI-C-1381-Daicel

Phytonadione Dihydroxy Epoxide Impurity – Diastereomer-4

  • CAT Number DCTI-C-001381
  • CAS Number NA
  • Molecular Formula C31H48O5
  • Molecular Weight 500.72
Phytonadione Dihydroxy Epoxy Impurity - Diastereomer-5

Phytonadione Dihydroxy Epoxy Impurity – Diastereomer-5

  • CAT Number DCTI-C-001659
  • CAS Number NA
  • Molecular Formula C31H48O5
  • Molecular Weight 500.72
Phytonadione Dihydroxy Epoxy Impurity - Diastereomer-6

Phytonadione Dihydroxy Epoxy Impurity – Diastereomer-6

  • CAT Number DCTI-C-001660
  • CAS Number NA
  • Molecular Formula C31H48O5
  • Molecular Weight 500.72
Phytonadione-DCTI-C-1372-Daicel

Phytonadione Diol Impurity-1

  • CAT Number DCTI-C-001372
  • CAS Number NA
  • Molecular Formula C31H48O4
  • Molecular Weight 484.72
Phytonadione-DCTI-C-1373-Daicel

Phytonadione Diol Impurity-2

  • CAT Number DCTI-C-001373
  • CAS Number NA
  • Molecular Formula C31H48O4
  • Molecular Weight 484.72

Phytonadione Diol Impurity-3

  • CAT Number DCTI-C-001374
  • CAS Number NA
  • Molecular Formula C31H48O4
  • Molecular Weight 484.72
Phytonadione-DCTI-C-1375-Daicel

Phytonadione Diol Impurity-4

  • CAT Number DCTI-C-001375
  • CAS Number NA
  • Molecular Formula C31H48O4
  • Molecular Weight 484.72
Phytonadione Diol Impurrity

Phytonadione Diol Impurrity

  • CAT Number DCTI-C-000045
  • CAS Number 107759-10-4
  • Molecular Formula C31H48O4
  • Molecular Weight 484.72
Phytonadione epoxy Impurity (Mixture of Trans and Cis)

Phytonadione epoxy Impurity (Mixture of Trans and Cis)

  • CAT Number DCTI-C-000091
  • CAS Number NA
  • Molecular Formula C31H46O3
  • Molecular Weight 466.71
Phytonadione Impurity A

Phytonadione Impurity A

  • CAT Number DCTI-C-000119
  • CAS Number 58-27-5
  • Molecular Formula C11H8O2
  • Molecular Weight 172.18
Phytonadione Impurity B

Phytonadione Impurity B

  • CAT Number DCTI-C-000117
  • CAS Number 604-87-5
  • Molecular Formula C35H52O4
  • Molecular Weight 536.8
Phytonadione-DCTI-C-1377-Daicel

Phytonadione Peroxy Impurity – Diastereomer-1

  • CAT Number DCTI-C-001377
  • CAS Number NA
  • Molecular Formula C31H48O4
  • Molecular Weight 484.72
Phytonadione-DCTI-C-1378-Daicel

Phytonadione Peroxy Impurity – Diastereomer-2

  • CAT Number DCTI-C-001378
  • CAS Number NA
  • Molecular Formula C31H48O4
  • Molecular Weight 484.72
Phytonadione Photodegradation Impurity

Phytonadione Photodegradation Impurity

  • CAT Number DCTI-C-000042
  • CAS Number 15576-39-3
  • Molecular Formula C31H46O4
  • Molecular Weight 482.71
Phytonadione related impurity

Phytonadione related impurity

  • CAT Number DCTI-C-000182
  • CAS Number 19274-66-9
  • Molecular Formula C31H46O2
  • Molecular Weight 450.71
Phytonadione Thermal Degradation Impurity

Phytonadione Thermal Degradation Impurity

  • CAT Number DCTI-C-000043
  • CAS Number 15576-40-6
  • Molecular Formula C31H46O3
  • Molecular Weight 466.71
Phytonadione Trans-I / Trans Phytonadione Diastereomer-1

Phytonadione Trans-I / Trans Phytonadione Diastereomer-1

  • CAT Number DCTI-C-000426
  • CAS Number NA
  • Molecular Formula C31H46O2
  • Molecular Weight 450.71
Phytonadione-DCTI-C-427-Daicel

Phytonadione Trans-III / Trans Phytonadione Diastereomer-2

  • CAT Number DCTI-C-000427
  • CAS Number NA
  • Molecular Formula C31H46O2
  • Molecular Weight 450.71
Trans Phytonadione Enantiomer

Phytonadione Trans-IV / Trans Phytonadione Enantiomer

  • CAT Number DCTI-C-000428
  • CAS Number NA
  • Molecular Formula C31H46O2
  • Molecular Weight 450.71
Phytonadione-DCTI-A-181-Daicel

Phytonadione-D7 ( Mixture of Cis & Trans)

  • CAT Number DCTI-A-000181
  • CAS Number NA
  • Molecular Formula C31H39D7O2
  • Molecular Weight 457.75
Phytonadione-DCTI-A-012-Daicel

Tran-Phytonadione-D7

  • CAT Number DCTI-A-000012
  • CAS Number NA
  • Molecular Formula C31H39D7O2
  • Molecular Weight 457.75
Trans Phytonadione 2,3-epoxide / Trans epoxy Phytonadione

Trans Phytonadione 2,3-epoxide / Trans epoxy Phytonadione

  • CAT Number DCTI-C-000118
  • CAS Number 1588773-08-3
  • Molecular Formula C31H46O3
  • Molecular Weight 466.71
Trans Phytonadione Epoxy Impurity

Trans Phytonadione Epoxy Impurity

  • CAT Number DCTI-C-000044
  • CAS Number 41018-27-3
  • Molecular Formula C31H46O3
  • Molecular Weight 466.71
Phytonadione-DCTI-A-009-Daicel

Trans-Phytonadione

  • CAT Number DCTI-A-000009
  • CAS Number 84-80-0
  • Molecular Formula C31H46O2
  • Molecular Weight 450.71
Vitamin K1 Related Compound 5 / Phytonadione Monoacetate Impurity

Vitamin K1 Related Compound 5 / Phytonadione Monoacetate Impurity

  • CAT Number DCTI-C-000669
  • CAS Number 50281-47-5
  • Molecular Formula C33H50O3
  • Molecular Weight 494.76
Vitamin K1 Related Compound-1

Vitamin K1 Related Compound-1

  • CAT Number DCTI-C-000205
  • CAS Number 22399-39-9
  • Molecular Formula C13H10O3
  • Molecular Weight 214.22
Phytonadione-DCTI-C-1382-Daicel

Vitamin K3-2,3-epoxide Impurity

  • CAT Number DCTI-C-001382
  • CAS Number 15448-59-6
  • Molecular Formula C11H8O3
  • Molecular Weight 188.18
?,?-Dihydro vitamin K1

β,γ-Dihydro vitamin K1

  • CAT Number DCTI-C-000518
  • CAS Number 1217521-73-7
  • Molecular Formula C31H48O2
  • Molecular Weight 452.72

General Information

Phytonadione Impurities and Phytonadione

Daicel Pharma is capable of offering Phytonadione impurity standards such as Phytonadione Impurity B, Phytonadione Impurity A, Phytonadione Diol Impurity, Phytonadione Diol Impurity-1 and more. The effectiveness, stability, and safety of Phytonadione is affected by impurities. Daicel Pharma can synthesize custom Phytonadione impurities according to global standards and regulations and worldwide delivery.

Phytonadione [CAS: 84-80-0] belongs to the class of phylloquinone. It functions as a cofactor, as a plant metabolite, and as a human metabolite. It is vitamin K and a phylloquinone member.

Phytonadione: Use and Commercial Availability

Oral phylloquinone treats prothrombin deficiency. It also treats hypoprothrombinemia. Parenteral phylloquinone (administered through intravenous, intramuscular, or subcutaneous routes) treats coagulation disorders caused by deficiencies in the production of coagulation factors II, VII, IX, and X due to vitamin K deficiency or any interference with vitamin K activity. This medicine is available under brand names such as Aquamephyton, Konakion, Mephyton, Vitamin K1, and Vitaped.

Phytonadione Structure and Mechanism of ActionPhytonadione Structure and Mechanism of Action

The chemical name of Phytonadione is 2-Methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecen-1-yl]-1,4-naphthalenedione. Its chemical formula is C31H46O2, and its molecular weight is approximately 450.7 g/mol.

Phytonadione is necessary for the formation of prothrombinogen and other blood clotting factors in the liver.

Phytonadione Impurities and Synthesis

Phytonadione impurities refer to unintended substances or contaminants present in Phytonadione1, a synthetic form of vitamin K. These impurities can impact the product’s effectiveness, stability, and safety.

Daicel Pharma provides a Certificate of Analysis (CoA) for various Phytonadione impurity standards, including Phytonadione Impurity B, Phytonadione Impurity A, Phytonadione Diol Impurity, Phytonadione Diol Impurity-1, and more. Our analytical facility, certified under cGMP, issues a comprehensive CoA and detailed characterization information such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. Additional characterization details, like 13C-DEPT, can be provided upon request. Daicel Pharma is qualified to provide Phytonadione impurities and labeled compounds for assessing the effectiveness of generic Phytonadione. We offer highly pure Cis-Phytonadione-D7, Phytonadione-D7 (Mixture of Cis & Trans), and Tran-Phytonadione-D7, deuterium-labeled Phytonadione standard, essential for bioanalytical research and Bioavailability/Bioequivalence (BA/BE) studies.

References
FAQ's

References

  1. Isler, Otto; Doebel, Karl, Synthesis Of Vitamin K1 Using Boron Trifluoride Catalysts, Hoffmann-La Roche Inc., US2683176A, July 6, 1954
  2. Horn, George B., Determination of phytonadione in elemental diets by TLC-spectrophotodensitometry, Journal of Pharmaceutical Sciences, Volume: 67, Issue: 6, Pages: 834-6, 1978

Frequently Asked Questions

Complete removal of Phytonadione impurities is achievable through appropriate purification processes and quality control measures.

Yes, there are regulatory guidelines in place for Phytonadione impurities.

Pharmaceutical manufacturers take several measures to minimize impurities in Phytonadione. These include employing Good Manufacturing Practices (GMP), using high-quality raw materials, optimizing preparing processes, implementing proper storage and handling procedures, and conducting regular testing and monitoring to ensure product quality and purity.

Phytonadione impurities are stored at a regulated room temperature of 2-8°C or as specified on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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