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Ondansetron 13CD3

  • CAT Number DCTI-A-138
  • CAS Number 99614-02-5(Unlabelled)
  • Molecular Formula C17H13CH16D3N3O
  • Molecular Weight 297.38

Ondansetron D3

  • CAT Number DCTI-A-124
  • CAS Number 1132757-82-4
  • Molecular Formula C18H16D3N3O
  • Molecular Weight 296.39

Ondansetron Impurity

  • CAS NUMBER 110708-17-3

Ondansetron impurity-C

  • CAT Number DCTI-C-820
  • CAS Number 27387-31-1
  • Molecular Formula C13H13NO
  • Molecular Weight 199.25

Ondansetron Impurity-G

  • CAT Number DCTI-C-821
  • CAS Number 99614-03-6
  • Molecular Formula C17H17N3O
  • Molecular Weight 279.34

Ondansetron Impurity-H

  • CAT Number DCTI-C-1175
  • CAS Number 99614-14-9
  • Molecular Formula C17H17N3O
  • Molecular Weight 279.34

Ondansetron Impurity-I

  • CAT Number DCTI-C-1500
  • CAS Number 15128-52-6
  • Molecular Formula C12H11NO
  • Molecular Weight 185.23

Ondansetron Related compound – D

  • CAT Number DCTI-C-822
  • CAS Number 99614-64-9
  • Molecular Formula C14H13NO
  • Molecular Weight 211.26

Ondansetron Related Compound A

  • CAS NUMBER 153139-56-1

General Information

Ondansetron Impurities and Ondansetron 

Daicel Pharma offers Ondansetron impurities that involve Ondansetron impurity-C, Ondansetron Impurity-G, Ondansetron Impurity-H, Ondansetron Impurity-I, Ondansetron Related Compound A, Ondansetron Related compound – D. These impurities have a role in determining the quality, stability, and safety of Ondansetron, a pharmaceutically active component. Daicel Pharma is capable of synthesizing Ondansetron impurities and distributing them worldwide.

Ondansetron [CAS: 99614-02-5] works as a serotonin type-3 antagonist for treating nausea and vomiting.

Ondansetron: Use and Commercial Availability  

Ondansetron reduces nausea and vomiting caused by emetogenic cancer treatment, postoperative care, and radiation. It helps to alleviate postoperative nausea and vomiting. Ondansetron is a frequently used medication for children and teens following head trauma and concussion. Ondansetron comes in different dosage forms, including oral pills, disintegrating tablets, and injectables. It is widely available commercially under several brand names, Zofran and Zuplenz.

Ondansetron Structure and Mechanism of Action

The chemical name of Ondansetron is 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one. Its chemical formula is C18H19N3O, and its molecular weight is approximately 293.4 g/mol.

Its mechanism of action is not known.

Ondansetron Impurities and Synthesis

During the synthesis of Ondansetron impurities, a medication commonly used to prevent nausea and vomiting, impurities can form. These impurities may arise from incomplete reactions, undesired side reactions, or contaminants in the starting materials or reagents. The synthesis1 of Ondansetron involves multiple steps, including reacting various intermediates to form the final product.

Daicel provides a Certificate of Analysis (CoA) of Ondansetron impurity standards such as Ondansetron impurity-C, Ondansetron Impurity-G, Ondansetron Impurity-H, Ondansetron Impurity-I, Ondansetron Related Compound A, and Ondansetron Related compound – D. Daicel delivers a Certificate of Analysis (CoA) from a cGMP-certified analytical facility for Ondansetron impurities. Our CoA contains extensive characterization information, including 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. We give additional characterization information, including 13C-DEPT, on request. Our specialists provide the extremely pure Ondansetron D3, Ondansetron 13CD3, deuterated-labeled standards of Ondansetron needed for bioanalytical research, and Bioavailability/Bioequivalence (BA/BE) studies.


Frequently Asked Questions

For any pharmaceutical product, including Ondansetron, removing all contaminants is difficult. However, manufacturers reduce impurities using improved synthesis procedures, purification methods, and strict quality control. Impurity levels must be below the permitted limits established by regulatory bodies to guarantee the safety and effectiveness of Ondansetron.

It is vital to ensure drug safety, effectiveness, and quality by identifying, measuring, and regulating undesirable chemicals that may harm patients or interfere with Ondansetron's intended therapeutic activity.

Ondansetron impurities are synthesized through various mechanisms during manufacturing, storage, and degradation, arising from incomplete reactions, undesired side reactions, or contaminants in starting materials. Controlling and minimizing them is vital for ensuring Ondansetron's quality and purity.

Ondansetron Impurities are stored at a regulated room temperature of 2-8°C or as specified on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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