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N-Demethyl Olanzapine

  • CAT Number DCTI-C-878
  • CAS Number 161696-76-0
  • Molecular Formula C16H18N4S
  • Molecular Weight 298.41

N-Desmethyl Olanzapine D8

  • CAS NUMBER 786686-82-6

Olanzapine BP Impurity-3

  • CAT Number DCTI-C-702
  • CAS Number 1017241-34-7
  • Molecular Formula C17H20N4O2
  • Molecular Weight 312.37

Olanzapine degradation impurities 1 and 2


Olanzapine Related Compound A

  • CAT Number DCTI-C-879
  • CAS Number 138564-59-7
  • Molecular Formula C12H9N3O2S
  • Molecular Weight 259.28

Olanzapine Related Compound B

  • CAT Number DCTI-C-880
  • CAS Number 221176-49-4
  • Molecular Formula C12H10N2OS
  • Molecular Weight 230.29

Olanzapine Thiolactam Impurity

  • CAT Number DCTI-C-877
  • CAS Number 1017241-36-9
  • Molecular Formula C17H20N4OS
  • Molecular Weight 328.43


  • CAT Number DCTI-A-041
  • CAS Number 786686-79-1
  • Molecular Formula C17H17D3N4S
  • Molecular Weight 315.45

General Information

Olanzapine Impurities and Olanzapine

Daicel Pharma offers Olanzapine impurities such as N-Demethyl Olanzapine, Olanzapine BP Impurity-3, Olanzapine degradation impurities 1 and 2, Olanzapine Related Compound A, Olanzapine Related Compound B, and Olanzapine Thiolactam Impurity. These impurities are critical for determining the quality, stability, and safety of Olanzapine, an active pharmaceutical component. Daicel Pharma custom synthesizes and distributes Olanzapine impurities globally.

Olanzapine [CAS: 132539-06-1] is a thienobenzodiazepine derivative. It functions as a histamine antagonist, muscarinic antagonist, serotonin antagonist, dopaminergic antagonist, antiemetic, second-generation antipsychotic, and serotonin uptake inhibitor. It contains benzodiazepines, N-methylpiperazines, and N-arylpiperazines.

Olanzapine: Use and Commercial Availability  

Olanzapine’s use orally and intramuscularly treats persistent schizophrenia and other mental diseases, such as bipolar disorder, including mixed or manic episodes in patients. Olanzapine also has approval for the short-term treatment of acute manic or mixed episodes associated with bipolar I disorder in adults when combined with lithium or valproate. Olanzapine treats moderate to severe manic episodes. Olanzapine prevents recurrence in patients with bipolar disorder whose manic episode has responded to Olanzapine therapy. Olanzapine is available as Zyprexa, Zyprexa Zydis, and Zyprexa Relprevv.

Olanzapine Structure and Mechanism of Action Olanzapine Structure and Mechanism of Action

The chemical name of Olanzapine is 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine. Its chemical formula is C17H20N4S, and its molecular weight is approximately 312.4 g/mol.

The mechanism of action of Olanzapine is unknown concerning other drugs.

Olanzapine Impurities and Synthesis

Olanzapine impurities are unwanted substances that can be present in the drug formulation of Olanzapine. They can arise during synthesis1, storage, or degradation processes. Controlling impurities is essential for maintaining the quality and effectiveness of Olanzapine.

Daicel provides a Certificate of Analysis (CoA) of Olanzapine impurities such as N-Demethyl Olanzapine, Olanzapine BP Impurity-3, Olanzapine degradation impurities 1 and 2, Olanzapine Related Compound A, Olanzapine Related Compound B, and Olanzapine Thiolactam Impurity. Our cGMP-compliant analytical laboratory offers the CoA, which contains extensive characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. We give additional characterization data, such as 13C-DEPT, on request. Fortunately, Daicel Pharma has a team of specialists to offer Olanzapine unknown impurities. Our professionals provide exceptionally pure Olanzapine-D3, deuterium-labeled standards of Olanzapine that are essential for bioanalytical research and Bioavailability/Bioequivalence (BA/BE) studies.


Frequently Asked Questions

During manufacturing, strict quality control procedures help manage Olanzapine impurities. Impurity levels are subject to regulatory bodies' limitations.

During the synthetic process of Olanzapine, unintended chemical reactions or side reactions can occur, leading to the formation of impurities. These impurities can result from incomplete reactions, unexpected intermediates, or variations in reaction conditions.

During synthesis, Olanzapine impurities are controlled by utilizing established analytical techniques, monitoring reaction conditions, and adopting quality control measures.

Olanzapine impurities are stored at a regulated room temperature of 2-8°C or as specified on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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