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2,6-Diaminopurine arabinoside

  • CAT Number DCTI-C-1700
  • CAS Number 34079-68-0
  • Molecular Formula C10H14N6O4
  • Molecular Weight 282.26

9-(Beta-d-arabino furanosyl) Guanine

  • CAT Number DCTI-C-1699
  • CAS Number 38819-10-2
  • Molecular Formula C10H13N5O5
  • Molecular Weight 283.24
Nelarabine Alpha isomer impurity
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Nelarabine Alpha isomer impurity

  • CAT Number DCTI-C-1296
  • CAS Number 1305196-84-2
  • Molecular Formula C11H15N5O5
  • Molecular Weight 297.27

Nelarabine impurity 17

  • MOLECULAR FORMULA C6H9N5O2 (free base); C6H10ClN5O2 (HCl salt)
  • MOLECULAR WEIGHT 183.17(free base); 219.63 (HCl salt)
Nelarabine Stage-1 Impurity
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Nelarabine Stage-1 Impurity

  • CAT Number DCTI-C-1498
  • CAS Number 1173825-84-7
  • Molecular Formula C32H27Cl6N5O5
  • Molecular Weight 774.29

General Information

Nelarabine Impurities and Nelarabine  

Daicel Pharma is a trusted provider of quality Nelarabine impurity standards, including 2,6-Diaminopurine arabinoside, 9-(Beta-d-arabino furanosyl) Guanine, Nelarabine Alpha isomer impurity, Nelarabine impurity 17, and Nelarabine Stage-1 Impurity. These impurities are critical in determining the active pharmaceutical ingredient Nelarabine’s quality, stability, and biological safety. Additionally, Daicel Pharma can synthesize Nelarabine impurities according to precise customer specifications while guaranteeing worldwide delivery.

Nelarabine [CAS: 121032-29-9] is a pro-drug of the deoxyguanosine analog, 9-β-Darabinofuranosylguanine (ara-G). It treats patients diagnosed with T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) who have not shown a response to or have experienced a relapse after undergoing at least two chemotherapy regimens.

Nelarabine: Use and Commercial Availability   

Nelarabine treats T-cell acute lymphoblastic leukemia, a rare type of non-Hodgkin lymphoma primarily affecting lymph nodes. It is for patients who have not responded to or have relapsed following treatment with at least two chemotherapy regimens. Nelarabine helps in targeting and killing these cancer cells.

Nelarabine is available under the brand name, Arranon active ingredient Nelarabine.

Nelarabine Structure and Mechanism of Action Nelarabine Structure and Mechanism of Action

The chemical name of Nelarabine is 9-β-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine. Its chemical formula is C11H15N5O5, and its molecular weight is approximately 297.27 g/mol.

Nelarabine is converted to the active 5’-triphosphate, ara-GTP, after demethylation by adenosine deaminase (ADA). Nelarabine inhibits DNA synthesis and cell death after ara-GTP accumulation in leukemic blasts.

Nelarabine Impurities and Synthesis

Nelarabine impurities can arise during synthesis1 due to the storage or use of specific raw materials and intermediates in manufacturing. These impurities encompass related compounds, degradation products, and process impurities. Stringent quality control measures and analytical methods are crucial to ensure the purity and safety of Nelarabine for patient use.

Daicel Pharma provides a comprehensive Certificate of Analysis (CoA) for Nelarabine impurity standards, such as 2,6-Diaminopurine arabinoside, 9-(Beta-d-arabino furanosyl) Guanine, Nelarabine Alpha isomer impurity, Nelarabine impurity 17, and Nelarabine Stage-1 Impurity. The CoA includes detailed characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. Additionally, upon delivery, a complete 13C-DEPT is also provided. Daicel Pharma possesses the technology and expertise to synthesize any unknown Nelarabine impurity or degradation product.


Frequently Asked Questions

Analytical methods, such as high-performance liquid chromatography (HPLC), are commonly used to detect and quantify impurities in Nelarabine batches.

The specifications for Nelarabine impurities are determined through meticulous research, analysis, and adherence to regulatory guidelines.

Several chromatographic techniques can help in chiral separation, including high-performance liquid chromatography (HPLC). These methods utilize chiral stationary phases (CSPs) to selectively retain and separate the enantiomers based on their interactions with the stationary or mobile phase.

Nelarabine impurities should generally be stored at a controlled room temperature between 2-8 ⁰C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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