Methimazole

General Information

Methimazole Impurities and Methimazole

Daicel Pharma offers superior-quality Methimazole impurities and Labeled Standards. These impurities are essential for evaluating Methimazole quality, stability, and biological safety. In addition, Daicel Pharma specializes in the custom synthesis of Methimazole impurities and ensures their worldwide delivery.

Methimazole [CAS: 60-56-0] is a medicine to treat hyperthyroidism, specifically in cases where surgical or radioactive iodine therapy is unsuitable. It is an active metabolite of Carbimazole. It decreases the production of thyroid hormones thyroxine (T4) and triiodothyronine (T3). They regulate body growth, development, and metabolism.

Methimazole: Use and Commercial Availability  

Methimazole treats hyperthyroidism, wherein the body produces excessive thyroid hormones. It also treats Graves’ disease, an autoimmune disease that affects the thyroid gland. Methimazole treats patients with thyroid storm or thyrotoxicosis. In addition, it treats patients with toxic nodular goiters unsuitable for surgery. It is available as an oral formulation under Tapazole.

Methimazole Structure and Mechanism of Action

The chemical name of Methimazole is 3-methyl-1H-imidazole-2-thione . The chemical formula for Methimazole is C₄H₆N₂S, and its molecular weight is approximately 114.17 g/mol.

Methimazole prevents thyroid generation in the thyroid gland. It disturbs the enzymatic process intervened by thyroid peroxidase, which causes iodination of tyrosine residues in thyroglobulin. It inhibits the synthesis of T4 and T3 thyroid hormones.

Methimazole Impurities and Synthesis

While synthesizing Methimazole1, impurities may form that will affect drug safety and efficacy. They form during the synthetic process, storage, or purification of Methimazole. Manufacturers can control and monitor Methimazole impurities to improve the drug’s safety, efficacy, and storage.
Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Methimazole impurities and Labeled Standards. The CoA given to clients is from a cGMP-compliant analytical facility, which has the complete characterization data1 such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity². We give additional spectral data on request. Daicel Pharma can prepare any unidentified Methimazole impurity or degradation product. In addition, Daicel Pharma offers a highly purified, stable deuterium-labeled standard, the Methimazole Labelled Standard. Daicel Pharma provides a complete characterization report accompanying the delivery.