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  • CAS NUMBER 625406-13-5

General Information

Meclizine Impurities and Meclizine

Daicel Pharma offers superior-quality Meclizine impurities, such as N, N’-Bis(3′-Me-benzyl)-piperazine. It is vital for evaluating the quality, stability, and biological safety of Meclizine. In addition, Daicel Pharma specializes in the custom synthesis of Meclizine impurities and ensures their worldwide delivery.

Meclizine [CAS: 569-65-3] is an antihistamine for treating motion sickness. It helps to prevent and treat vomiting, dizziness, and nausea. In addition, it treats vertigo symptoms in diseases affecting the vestibular system. Meclizine is a non-selective histamine H1 antagonist.

Meclizine: Use and Commercial Availability

As a first-generation antihistamine, Meclizine treats motion sickness symptoms and controls vertigo. Further, it manages Mèniére disease. Meclizine treats acute attacks of vestibular migraine and achondroplasia. In radiotherapy treatment, Meclizine can treat radiation-induced vomiting. It is available as an oral medicine to patients. Antivert is the trade name of Meclizine.

Meclizine Structure and Mechanism of Action

Meclizine Structure and Mechanism of Action

The chemical name of Meclizine is 1-[(4-Chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine. The chemical formula for Meclizine is C25H27ClN2 and its molecular weight is approximately 390.95 g/mol.

Meclizine inhibits the vasodepressor response to histamine. It blocks the medulla’s vomiting center and decreases vestibular incitation.

Meclizine Impurities and Synthesis

While synthesizing Meclizine 1, impurities may form that affect the safety and efficacy of the drug. During production and storage of Meclizine, impurities form. Thus, the control and monitoring of Meclizine impurities is essential in every stage of drug development.

Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Meclizine impurities, which includes N, N’-Bis(3′-Me-benzyl)-piperazine. The CoA is from a cGMP-compliant analytical facility and encompasses complete characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. We give additional data like 13C-DEPT and CHN on request. Daicel Pharma can prepare any unidentified Meclizine impurity or degradation product. In addition, Daicel Pharma offers highly purified isotope-labeled standards of Meclizine for bioanalytical research and BA/BE studies. We also provide a complete characterization report on delivery.


Frequently Asked Questions

Synthesis precursors, degradation products, and photolysis result in forming Melatonin impurities.

5-Hydroxytryptamine, serotonin, N-Acetyl-5-hydroxytryptamine, N, O-Diacetyl-5-hydroxytryptamine, and 5-Methoxytryptamine are the potential, known impurities of Melatonin.

It is essential to control Melatonin impurities in the drug product to protect Melatonin's safety and efficacy.

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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