Hydralazine

General Information

Hydralazine Impurities and Hydralazine

Daicel Pharma offers the best quality Hydralazine impurities, such as Hydralazine Lactosone Ring-opened adduct. It is vital for evaluating Hydralazine quality, stability, and biological safety. In addition, Daicel Pharma specializes in the custom synthesis of Hydralazine impurities and ensures their worldwide delivery.

Hydralazine [CAS: 86-54-4] is an antihypertensive and arteriolar vasodilator. It treats hypertension. It is a 1-hydrazino derivative of phthalazine. Further, it is used alone or with other medicines for treating heart failure.

Hydralazine: Use and Commercial Availability

Hydralazine, as an oral antihypertensive, helps in dilating blood vessels. It lowers blood pressure by relaxing vascular smooth muscles. Hydralazine inhibits intracellular calcium release that causes smooth muscle contraction. Further, Hydralazine inhibits DNA methylation. It was a part of the studies on cervical cancer therapies. It is commercially available for parenteral and oral use. Many generic players use Hydralazine in combination with other medicines. Apresoline and Dralzine are some of the names under which Hydralazine is available.

Hydralazine Structure and Mechanism of Action

1-Hydrazinylphthalazine is the chemical name of Hydralazine. The chemical formula for Hydralazine is C₈H₈N₄, and its molecular weight is approximately 160.18 g/mol.

Though the mechanism of action of Hydralazine is not clearly understood, it affects the cardiovascular system.

Hydralazine Impurities and Synthesis

While preparing Hydralazine¹, impurities formation may affect drug safety, efficacy, and shelf-life. They may form during the synthesis, storage, or degradation of Hydralazine. It is necessary to control and monitor the Hydralazine impurities to prevent any adverse effects on drug efficacy and safety.

Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Hydralazine impurities, which includes Hydralazine Lactosone Ring-opened adduct. The CoA is from a cGMP-compliant analytical facility. It contains the complete characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity². We give additional data like 13C-DEPT and CHN on request. Daicel Pharma can prepare any unidentified Hydralazine impurity or degradation product. In addition, Daicel Pharma offers highly purified isotope-labeled standards of Hydralazine for bioanalytical research and BA/BE studies. We also provide a complete characterization report on delivery.