Felbamate

General Information

Felbamate Impurities and Felbamate

Daicel Pharma offers high-quality Felbamate impurities, such as N-Aminocarbonyl Felbamate. It is vital for evaluating the quality, stability, and biological safety of Felbamate. In addition, Daicel Pharma specializes in the custom synthesis of Felbamate impurities and ensures their worldwide delivery.

Felbamate [CAS: 25451-15-4], an antiepileptic, is a bis(carbamate ester) of 2-phenylpropane-1,3-diol. Its properties are similar to other anticonvulsant compounds. Further, Felbamate manages Lennox-Gastaut syndrome and focal seizures. It inhibits the N-methyl-D-aspartate (NMDA) receptor glycine binding site and blocks excitatory amino acids effects, thus suppressing seizure activity.

Felbamate: Use and Commercial Availability

Felbamate is an anticonvulsant that treats patients with epilepsy. It treats partial seizures in adult patients. In addition, Felbamate is a neuroprotective agent that helps in preventing seizures. Felbamate reduces seizure spread and increases seizure threshold. Felbamate is available under the name Felbatol and other trade names.

Felbamate Structure and Mechanism of Action

Felbamate has a chemical name, that is 2-Phenyl-1,3-propanediol dicarbamate. The chemical formula for Felbamate is C₁₁H₁₄N₂O₄ and its molecular weight is approximately 238.24 g/mol.

The mechanism of action for Felbamate is not clearly understood.

Felbamate Impurities and Synthesis

During the synthesis of Felbamate ¹, impurities may form that may affect the safety and efficacy of the drug. These impurities form during the synthesis, storage, or degradation of Felbamate. Felbamate impurities need control and monitoring to improve the drug’s safety, efficacy, and storage.

Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Felbamate impurities, which includes N-Aminocarbonyl Felbamate. The CoA is from a cGMP-compliant analytical facility. It contains the complete characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity^2,3. We give additional data like 13C-DEPT and CHN on request. Daicel Pharma can prepare any unidentified Felbamate impurity or degradation product. In addition, Daicel Pharma offers highly purified isotope-labeled standards of Felbamate for bioanalytical research and BA/BE studies. We also provide a complete characterization report on delivery.