Favipiravir

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3-hydroxypyrazine-2-carboxamide

  • CAT Number DCTI-C-994
  • CAS Number 55321-99-8
  • Molecular Formula C5H5N3O2
  • Molecular Weight 139.11

3,6-dichloropyrazine-2-carbonitrile

  • CAT Number DCTI-C-958
  • CAS Number 356783-16-9
  • Molecular Formula C5HCl2N3
  • Molecular Weight 173.98

6-bromo-3-hydroxypyrazine-2-carboxamide

  • CAT Number DCTI-C-995
  • CAS Number 259793-88-9
  • Molecular Formula C5H4BrN3O2
  • Molecular Weight 218.01

6-Chloro-3-hydroxypyrazine-2-carboxamide

  • CAT Number DCTI-C-996
  • CAS Number 259793-90-3
  • Molecular Formula C5H4ClN3O2
  • Molecular Weight 173.56

6-Chloroypyrazine-2-carbonitrile

  • CAT Number DCTI-C-1012
  • CAS Number 6863-74-7
  • Molecular Formula C5H2ClN3
  • Molecular Weight 139.54

Favipiravir fluoro Ribofuranose

  • CAT Number DCTI-C-1712
  • CAS Number NA
  • Molecular Formula C23H29F2N4O9P
  • Molecular Weight 574.47

Favipiravir Ribofuranose

  • CAT Number DCTI-C-1713
  • CAS Number NA
  • Molecular Formula C25H34FN4O10P
  • Molecular Weight 600.54

Favipiravir Ribofuranose metabolite

  • CAT Number DCTI-C-1714
  • CAS Number NA
  • Molecular Formula C10H12FN3O6
  • Molecular Weight 289.22

General Information

Favipiravir Impurities and Favipiravir 

Daicel Pharma offers high-quality impurities for Favipiravir, an active pharmaceutical ingredient. These impurities, including 3-hydroxypyrazine-2-carboxamide, 3,6-dichloropyrazine-2-carbonitrile, 6-bromo-3-hydroxypyrazine-2-carboxamide, 6-Chloro-3-hydroxypyrazine-2-carboxamide, 6-Chloroypyrazine-2-carbonitrile, Favipiravir fluoro Ribofuranose, Favipiravir Ribofuranose, and Favipiravir Ribofuranose metabolite, play a vital role in assessing the purity, reliability, and safety of Favipiravir. Daicel Pharma also offers a customized synthesis of Favipiravir impurities to cater to client requirements, with worldwide delivery options available.

Favipiravir [CAS: 259793-96-9] is an antiviral drug that is a pyrazine carboxamide derivative. It exhibits activity against RNA viruses by selectively inhibiting the RNA-dependent RNA polymerase of RNA viruses. Favipiravir treats influenza and is an antiviral agent and an RNA-directed RNA polymerase inhibitor. Furthermore, it also helps in combating coronaviruses.

Favipiravir: Use and Commercial Availability  

Favipiravir, known by the brand name Avigan, was initially approved in Japan in 2014 for treating cases of influenza that were unresponsive to conventional therapies. Its effectiveness in targeting various influenza strains has prompted investigations into its potential use against other viral infections, including Ebola and COVID-19. Favipiravir acts as a purine analog, substituting guanine or adenine during viral replication, thereby hindering the replication process. It can treat life-threatening infections such as Ebola, Lassa fever, and rabies, establishing its therapeutic value in these diseases.

Favipiravir Structure and Mechanism of Action Favipiravir Structure and Mechanism of Action

The chemical name of Favipiravir is 6-Fluoro-3,4-dihydro-3-oxo-2-pyrazinecarboxamide. Its chemical formula is C5H4FN3O2, and its molecular weight is approximately 157.10 g/mol.

Favipiravir selectively inhibits the influenza viral RNA-dependent RNA polymerase.

Favipiravir Impurities and Synthesis

Impurities in Favipiravir refer to unintended substances or byproducts present in the medication. They can arise during the synthesis1, manufacturing, or storage processes. They encompass related compounds, degradation products, residual solvents, or other impurities introduced during production or handling. They can impact Favipiravir purity, stability, and overall quality. Strict regulatory guidelines and quality control measures help monitor and control the levels of impurities to ensure the safety and effectiveness of Favipiravir medications. It is essential to minimize and manage them to uphold the integrity and therapeutic value of Favipiravir.

Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Favipiravir impurity standards, including 3-hydroxypyrazine-2-carboxamide, 3,6-dichloropyrazine-2-carbonitrile, 6-bromo-3-hydroxypyrazine-2-carboxamide, 6-Chloro-3-hydroxypyrazine-2-carboxamide, 6-Chloroypyrazine-2-carbonitrile, Favipiravir fluoro Ribofuranose, Favipiravir Ribofuranose, and Favipiravir Ribofuranose metabolite. They generate from an analytical facility that complies with cGMP standards. The CoA provides a detailed characterization report with data obtained through techniques such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity analysis2. We give additional data like 13C-DEPT upon request. Daicel Pharma synthesizes unknown Favipiravir impurities or degradation products. Every delivery has a complete characterization report.

References
FAQ's

Frequently Asked Questions

Various physicochemical characterization techniques, such as melting point determination, solubility studies, and spectroscopic analysis, help characterize impurities in Favipiravir formulations.

Some impurities in Favipiravir formulations may alter the drug's pharmacodynamic effects, affecting its mechanism of action or therapeutic outcomes.

Proper storage conditions, such as temperature and humidity control, and suitable packaging materials help minimize impurity formation or degradation in Favipiravir during storage and transportation.

Favipiravir impurities are stored at a controlled room temperature, 2-8 °C, or according to the Certificate of Analysis (CoA) specifications.

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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