Sort by

(R)-ethyl N-formyl-N-(1-phenylethyl) glycine

  • CAT Number DCTI-C-760
  • CAS Number 66514-85-0
  • Molecular Formula C13H17NO3
  • Molecular Weight 235.28

1H-imidazole, 1-[(1R)-1-phenylethyl]-

  • CAT Number DCTI-C-759
  • CAS Number 844658-92-0
  • Molecular Formula C11H12N2
  • Molecular Weight 172.23

Ethyl (R)-[(1-Phenylethyl)amino] acetate

  • CAT Number DCTI-C-761
  • CAS Number 66512-37-6
  • Molecular Formula C12H17NO2
  • Molecular Weight 207.27

Ethyl (R)-3-(1-phenylethyl)-2-thioxo-23-dihydro-1H...

  • CAT Number DCTI-C-762
  • CAS Number 84711-26-2
  • Molecular Formula C14H16N2O2S
  • Molecular Weight 276.35

Ethyl N-formyl-3-oxo-N-(1-phenylethyl)alaninate

  • CAT Number DCTI-C-763
  • CAS Number 83763-26-2
  • Molecular Formula C14H17NO4
  • Molecular Weight 263.29

Etomidate intermediate Nitroso impurity

  • CAT Number DCTI-C-1476
  • CAS Number 2765007-50-7
  • Molecular Formula C12H16N2O3
  • Molecular Weight 236.27

General Information

Etomidate Impurities and Etomidate  

Daicel Pharma synthesizes high-quality Etomidate impurities, (R)-ethyl N-formyl-N-(1-phenylethyl) glycine, 1H-imidazole, 1-[(1R)-1-phenylethyl]-, Ethyl (R)-[(1-Phenylethyl)amino] acetate, Ethyl N-formyl-3-oxo-N-(1-phenylethyl)alaninate, Etomidate intermediate Nitroso impurity, and Ethyl (R)-3-(1-phenylethyl)-2-thioxo-23-dihydro-1H-imidazole-4-carboxylate., crucial in analyzing the quality, stability, and biological safety of the active pharmaceutical ingredient, Etomidate. Moreover, Daicel Pharma offers custom synthesis of Etomidate impurities and delivers them globally.

Etomidate [CAS: 33125-97-2] is a short-acting anesthetic. It is an imidazole carboxylate derivative.

Etomidate: Use and Commercial Availability  

Etomidate is an anesthetic agent that acts quickly and has no analgesic properties. It is available under the trade name AMIDATE (intravenous administration). It is an ultrashort-acting, non-barbiturate hypnotic drug used during general anesthesia, rapid sequence intubation, and procedural sedation. Etomidate is also used to maintain anesthesia and short surgical procedures, such as reducing dislocated joints, cardioversion, and tracheal intubation.

Etomidate Structure and Mechanism of ActionEtomidate Structure and Mechanism of Action

The chemical name of Etomidate is (R)-Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate. Its chemical formula is C14H16N2O2, and its molecular weight is approximately 244.29 g/mol.

Etomidate is structurally different from other anesthetic agents. It interacts with gamma-Aminobutyric acid type A (GABAA) receptors, potentiating the effects of GABA.

Etomidate Impurities and Synthesis

Impurities in the drug substance and finished drug product may impact its safety and efficacy. So, the synthesis of Etomidate impurities helps identify, quantify, and evaluate the chemical properties and stability of the drug. Further, developing analytical methods to detect and quantify impurities is critical for drug quality control and regulatory compliance.

Daicel offers a Certificate of Analysis (CoA) from a cGMP-compliant analytical facility for Etomidate impurity standards, (R)-ethyl N-formyl-N-(1-phenylethyl) glycine, 1H-imidazole, 1-[(1R)-1-phenylethyl]-, Ethyl (R)-[(1-Phenylethyl)amino] acetate, Ethyl N-formyl-3-oxo-N-(1-phenylethyl)alaninate, Etomidate intermediate Nitroso impurity, and Ethyl (R)-3-(1-phenylethyl)-2-thioxo-23-dihydro-1H-imidazole-4-carboxylate. The CoA includes complete characterization data, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity1,2. We also provide 13C-DEPT and CHN on request. We give a complete characterization report on delivery. Daicel has the technology and expertise to prepare any unknown Etomidate impurity or degradation product.


Frequently Asked Questions

The potential risks associated with Etomidate impurities are toxicity and reduced efficacy of the drug causing harmful effects on patient's health.

Etomidate impurities can be detected and quantified using analytical techniques such as high-performance liquid chromatography (HPLC), gas chromatography (GC), and liquid chromatography-mass spectrometry (LC-MS).

Methanol is commonly used for the analysis of Etomidate and its impurities. However, Acetonitrile is for tanalyzing impurities, such as Etomidate intermediate Nitroso impurity.

Etomidate impurities are stored at a controlled room temperature between 2-8 ⁰C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

Back to Top
Product has been added to your cart