Efavirenz

General Information

Efavirenz Impurities and Efavirenz

Daicel Pharma offers high-quality Efavirenz impurities, Efavirenz Amino Alcohol, Efavirenz Amino alcohol ethyl carbamate, Efavirenz Amino Alcohol Methyl Carbamate, Efavirenz Amino alcohol Bis(ethoxycarbonyl), Efavirenz Benzoyl Amino Impurity, Efavirenz Quinoline analog, and N-Benzyl Efavirenz. They are vital for evaluating the quality, stability, and biological safety of Efavirenz. Furthermore, Daicel Pharma specializes in the custom synthesis of Efavirenz impurities and ensures their worldwide delivery.
Efavirenz [CAS: 154598-52-4] is USFDA-approved for treating and preventing human immunodeficiency virus (HIV) and HIV-1 infection. It is a non-nucleoside reverse transcriptase inhibitor (NNRTI), which is HIV-1 specific. Efavirenz, used in combination with other HIV medicines, is a part of antiretroviral therapy.

Efavirenz: Use and Commercial Availability

Efavirenz is a drug for treating HIV-1 infection in patients. Efavirenz is a part of the antiretroviral therapy (ART) regimens. The treatment involves its combination with other HIV medicines like Tenofovir or Emtricitabine. Treatment with Efavirenz can improve the quality of life of patients affected with HIV. Efavirenz is available under the name Sustiva.

Efavirenz Structure and Mechanism of Action

The chemical name of Efavirenz is (4S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one. The chemical formula for Efavirenz is C₁₄H₉ClF₃NO₂ and its molecular weight is approximately 315.68g/mol.

As a non-nucleoside reverse transcriptase inhibitor (NNRTI), Efavirenz binds to the non-catalytic site of the HIV reverse transcription enzyme. Efavirenz activity inhibits HIV-1 RT. It results in DNA chain termination and prevents HIV replication.

Efavirenz Impurities and Synthesis

During the synthesis of Efavirenz¹, impurities may form that may affect the safety and efficacy of the drug. These impurities form during the synthesis, storage, or degradation of Efavirenz. As a result, impurities must be controlled and monitored throughout the drug’s lifecycle.

Daicel Pharma offers a comprehensive Certificate of Analysis (CoA) for Efavirenz impurities, which includes Efavirenz Amino Alcohol, Efavirenz Amino alcohol ethyl carbamate, Efavirenz Amino Alcohol Methyl Carbamate, Efavirenz Aminoalcohol Bis(ethoxycarbonyl), Efavirenz Benzoyl Amino Impurity, Efavirenz Quinoline analog, and N-Benzyl Efavirenz. The CoA is from a cGMP-compliant analytical facility and encompasses complete characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity². We give additional data like 13C-DEPT and CHN on request. Daicel Pharma can prepare any unidentified Efavirenz impurity or degradation product. In addition, Daicel Pharma offers highly purified isotope-labeled standards of Efavirenz for bioanalytical research and BA/BE studies. We also provide a complete characterization report on delivery.