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Cisatracurium
References
FAQ's
References
- Hill, Derek A.; Turner, Geoffrey L., Neuromuscular blocking agents, Burroughs Wellcome Co., United States, US5453510A, Sep 26, 1995
- Bryant, B. J.; James, Charles D. Jr.; Cook, D. Ryan; Harrelson, Jane Croft, High performance liquid chromatographic assay for cisatracurium and its metabolites in human urine, Journal of Liquid Chromatography & Related Technologies, Volume: 20, Issue: 13, Pages: 2041-2051, 1997
- Gao, Jieying; Yang, Ting; Ye, Mao; Zhang, Xiaoqing; Tian, Gang; Zhen, Qianna; Ding, Min, High-performance liquid chromatography assay with programmed flow elution for cisatracurium in human plasma: Application to pharmacokinetics in infants and children, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, Volume: 955-956, Pages: 58-63, 2014
Frequently Asked Questions
What is the purpose of synthesizing Cisatracurium impurities?
Synthesizing Cisatracurium impurities helps identify and quantify the impurities present in Cisatracurium besylate, a neuromuscular blocking agent used during surgery. It is essential for quality control and ensuring the safety and efficacy of the drug.
How are Cisatracurium impurities detected and quantified?
The detection and quantification of Cisatracurium impurities typically involve analytical techniques such as high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS), etc.
Which solvent is used for the analysis of Cisatracurium impurities?
Methanol, DCM (Dichloromethane), or DMSO (Dimethyl sulfoxide) are the solvents used based on the impurity profile of Cisatracurium and its impurities.
What is the temperature to store Cisatracurium impurities?
Cisatracurium impurities storage is at a controlled room temperature between 2-8 ⁰C. However, impurities such as Cisatracurium Besylate EP Impurity-Q are stored at -20 ⁰C as per the stability of the compound.
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