Cefuroxime

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Cefuroxime axetil Delta-3 Isomers

  • CAT Number DCTI-C-1384
  • CAS Number 123458-61-7
  • Molecular Formula C20H22N4O10S
  • Molecular Weight 510.47

Cefuroxime axetil dimer

  • CAT Number DCTI-C-807
  • CAS Number NA
  • Molecular Formula C36H38N8O17S2
  • Molecular Weight 918.86

Cefuroxime axetil Sulfoxide Diastereoisomer-A

  • CAT NUMBER DCTI-C-2780
  • CAS NUMBER 136235-54-6 (For Racemic Mixture)
  • MOLECULAR FORMULA C20H22N4O11S
  • MOLECULAR WEIGHT 526.47

Cefuroxime axetil Sulfoxide Diastereoisomer-B

  • CAT NUMBER DCTI-C-2781
  • CAS NUMBER 136235-54-6 (For Racemic Mixture)
  • MOLECULAR FORMULA C20H22N4O11S
  • MOLECULAR WEIGHT 526.47

Cefuroxime axetildiastereoisomers-A

  • CAT NUMBER DCTI-C-3655
  • CAS NUMBER 64599-29-7
  • MOLECULAR FORMULA C20H22N4O10S
  • MOLECULAR WEIGHT 510.47

Cefuroxime axetildiastereoisomers-B

  • CAT NUMBER DCTI-C-3654
  • CAS NUMBER 64599-28-6
  • MOLECULAR FORMULA C20H22N4O10S
  • MOLECULAR WEIGHT 510.47

General Information

Cefuroxime Impurities and Cefuroxime 

Daicel Pharma synthesizes high-quality Cefuroxime impurities, Cefuroxime axetil Delta-3 Isomers, and Cefuroxime axetil dimer, which are crucial in the analysis of the quality, stability, and biological safety of the active pharmaceutical ingredient Cefuroxime. Moreover, Daicel Pharma offers custom synthesis of Cefuroxime impurities and delivers them globally.

Cefuroxime [CAS: 55268-75-2] is an antibacterial medicine belonging to the group of second-generation cephalosporins. It is semi-synthetic and has a broad spectrum of activity against bacteria.

Cefuroxime: Use and Commercial Availability  

Cefuroxime is an antibiotic that treats various bacterial infections, including ear infections, bronchitis, skin infections, sinusitis, tonsillitis, gonorrhea, and urinary tract infections. It is available under brand names such as Zinacef, Ceftin, Cefuroxime Axetil, and Cefuroxime Sodium.

Cefuroxime Structure and Mechanism of Action Cefuroxime Structure and Mechanism of Action

The chemical name of Cefuroxime is (6R,7R)-3-[[(Aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-(2-furanyl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. Its chemical formula is C16H16N4O8S, and its molecular weight is approximately 424.4 g/mol.

Cefuroxime inhibits bacterial cell wall synthesis and leads to cell lysis.

Cefuroxime Impurities and Synthesis

Cefuroxime is a cephalosporin antibiotic that is prone to the formation of impurities during its manufacturing1 and storage. Impurities may form due to the degradation of the active pharmaceutical ingredient2 or through the reaction of the active ingredient with other compounds. Controlling and minimizing the formation of impurities in Cefuroxime is critical to ensure its quality and safety for use in patients.

Daicel offers a Certificate of Analysis (CoA) from a cGMP-compliant analytical facility for Cefuroxime impurity standards, Cefuroxime axetil Delta-3 Isomers, and Cefuroxime axetil dimer. The CoA includes complete characterization data, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity3. We also provide 13C-DEPT and CHN on request. We give a complete characterization report on delivery. Daicel has the technology and expertise to prepare any unknown Cefuroxime impurity or degradation product.

References
FAQ's

Frequently Asked Questions

Cefuroxime impurities can affect the drug's efficacy by interfering with its pharmacological activity or causing adverse effects on health.

Cefuroxime impurities are controlled during the manufacturing process by implementing measures such as process optimization, impurity profiling, and quality control testing.

Acetonitrile is used as a solvent in analyzing Cefuroxime impurities.

Cefuroxime impurities are stored at a controlled room temperature between 2-8 ⁰C or as            indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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