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Cefoxitin delactam amide lactone (mixture of diastereomers)

  • CAT Number DCTI-C-1723
  • CAS Number NA
  • Molecular Formula C15H17N3O5S2
  • Molecular Weight 383.44

Cefoxitin Delactam Lactone (Mixture Of Diastereomers)

  • CAT Number DCTI-C-1722
  • CAS Number NA
  • Molecular Formula C15H16N2O6S2
  • Molecular Weight 384.42
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Cefoxitin Lactone

  • CAT Number DCTI-C-1469
  • CAS Number 1422023-33-3
  • Molecular Formula C15H14N2O5S2
  • Molecular Weight 366.4

Descarbamoyloxy Cefoxitin

  • CAT Number DCTI-C-1721
  • CAS Number 40514-94-1
  • Molecular Formula C15H16N2O5S2
  • Molecular Weight 368.42

Desmethoxy cefoxitin

  • CAT Number DCTI-C-1725
  • CAS Number 37051-05-1
  • Molecular Formula C15H15N3O6S2
  • Molecular Weight 397.42

Methoxy Cefoxitin 1& 2

  • CAT Number DCTI-C-1726
  • CAS Number 2410854-09-8
  • Molecular Formula C17H19N3O8S2
  • Molecular Weight 457.47

General Information

Cefoxitin Impurities and Cefoxitin 

Daicel Pharma synthesizes Cefoxitin impurities of exceptional quality, such as Cefoxitin delactam amide lactone (mixture of diastereomers), Cefoxitin Delactam Lactone (Mixture of diastereomers), Cefoxitin Lactone, Descarbamoyloxy Cefoxitin, Desmethoxy Cefoxitin and Methoxy Cefoxitin 1& 2. These impurities are crucial to assess the purity, reliability, and safety of an active pharmaceutical ingredient, Cefoxitin. Besides, Daicel Pharma provides custom synthesis of Cefoxitin impurities to meet clients’ demands for delivery worldwide.

Cefoxitin [CAS: 35607-66-0] is a semi-synthetic cephamycin antibiotic with broad-spectrum antibacterial activity. It is resistant to beta-lactamase and derived from cephamycin C, which is produced by Streptomyces lactamdurans.

Cefoxitin: Use and Commercial Availability  

Cefoxitin is a cephalosporin antibiotic that exhibits excellent activity against anaerobic organisms and is effective against B. fragilis. It is resistant to hydrolysis by most gram-negative β-lactamases and some gram-positive bacteria. It treats infections caused by facultative gram-negative bacilli and anaerobes. It is effective for treating pelvic inflammatory disease when combined with doxycycline. Cefoxitin is available under the tradename Mefoxin.

Cefoxitin Structure and Mechanism of Action Cefoxitin Structure and Mechanism of Action

The chemical name of Cefoxitin is (6R,7S)-3-[[(Aminocarbonyl)oxy]methyl]-7-methoxy-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. Its chemical formula is C16H17N3O7S2, and its molecular weight is approximately 427.5 g/mol.

Cefoxitin inhibits bacterial cell wall synthesis and is active against gram-positive and gram-negative organisms.

Cefoxitin Impurities and Synthesis

Cefoxitin has impurities that appear during manufacturing1 or storage. They are related to the drug substance or the drug product. They can affect the drug’s quality, safety, and efficacy. So, it is necessary to control and monitor the Cefoxitin impurities to ensure the drug’s purity and safety. Control of Cefoxitin impurities can be through various measures such as process optimization, appropriate storage conditions, and analytical methods for impurity identification and quantification.

Daicel Pharma offers a Certificate of Analysis (CoA) for Cefoxitin impurity standards, such as Cefoxitin delactam amide lactone (mixture of diastereomers), Cefoxitin Delactam Lactone (Mixture of diastereomers), Cefoxitin Lactone, Descarbamoyloxy Cefoxitin, Desmethoxy Cefoxitin and Methoxy Cefoxitin 1& 2, generated from an analytical facility compliant with cGMP standards. The CoA includes a comprehensive characterization report comprising data from techniques like 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. Furthermore, on request, we give additional data like 13C-DEPT and CHN. Daicel Pharma can synthesize unknown Cefoxitin impurities or degradation products. A complete characterization report accompanies every delivery.


Frequently Asked Questions

Impurities in Cefoxitin develop during the manufacturing process, storage, and transportation. They arise from starting materials, intermediates, or reaction by-products. Environmental factors like temperature, humidity, and light can also cause impurity formation.

Impurities in Cefoxitin are controlled by monitoring the manufacturing process, storing the drug under appropriate conditions, and conducting quality control tests using validated analytical methods.

Cefoxitin impurities are stored at a controlled room temperature between 2-8 °C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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