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Bendamustine
References
FAQ's
References
- Chen, Jian; Przyuski, Katrin; Roemmele, Renee Caroline, Processes For The Preparation Of Bendamustine, Cephalon, Inc., United States, EP2346836B1, March 7, 2018
- Dubbelman, A. C.; Tibben, M.; Rosing, H.; Gebretensae, A.; Nan, L.; Gorman, S. H.; Robertson, P. Jr.; Schellens, J. H. M.; Beijnen, J. H., Development and validation of LC-MS/MS assays for the quantification of bendamustine and its metabolites in human plasma and urine, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, Volume: 893-894, Pages: 92-100, 2012
Frequently Asked Questions
What are the residual solvents in Bendamustine?
Residual solvents in Bendamustine are impurities that linger after the synthetic process and can be harmful if present in high amounts.
How are the process-related impurities controlled in Bendamustine?
The control of process-related impurities in Bendamustine is possible by using high-quality starting materials, optimizing reaction conditions, and implementing the correct purification steps.
Which solvent helps in the analysis of Bendamustine impurities?
Methanol or DMSO are solvents used in analyzing many impurities in Bendamustine.
What are the temperature conditions required to store Bendamustine impurities?
Bendamustine impurities are stored at a controlled room temperature between 2-8 °C or as indicated on the Certificate of Analysis (CoA).
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