Atazanavir

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(+)-Tert-butyl ((R)-1-((R)-oxiran-2-yl)-2-phenylethyl) carbamate

  • CAT Number DCTI-C-1880
  • CAS Number 156474-21-4
  • Molecular Formula C15H21NO3
  • Molecular Weight 263.33

Atazanavir Ditertbutyl Analog

  • CAT NUMBER DCTI-C-3361
  • CAS NUMBER 198904-86-8
  • MOLECULAR FORMULA C32H42N4O5
  • MOLECULAR WEIGHT 562.71

Atazanavir Hydrazine Analog TFA Salt

  • CAT Number DCTI-C-1706
  • CAS Number NA
  • Molecular Formula C26H26F6N4O3
  • Molecular Weight 556.51

Atazanavir Labelled Standard

  • CAT Number DCTI-A-030
  • CAS Number 1092540-50-5
  • Molecular Formula C38H46D6N6O7
  • Molecular Weight 710.89

ATAZANAVIR SULFATE ATARC-1

  • CAT Number DCTI-C-1820
  • CAS Number NA
  • Molecular Formula C38H52N6O7
  • Molecular Weight 704.87

General Information

Atazanavir Impurities and Atazanavir  

Daicel Pharma synthesizes high-quality Atazanavir impurities, including (+)-Tert-butyl ((R)-1-((R)-oxiran-2-yl)-2-phenylethyl) carbamate, Atazanavir Hydrazine Analog TFA Salt, and ATAZANAVIR SULFATE ATARC-1. These impurities are essential for evaluating the quality, stability, and safety of Atazanavir, which is an active pharmaceutical ingredient. Additionally, Daicel Pharma offers a customized synthesis of Atazanavir impurities for global delivery to meet the specific needs of our customers.

Atazanavir [CAS: 198904-31-3] is an antiretroviral drug that treats and prevents human immunodeficiency virus (HIV-1) infection and acquired immunodeficiency syndrome (AIDS). It does not elevate serum lipids like other protease inhibitors.

Atazanavir: Use and Commercial Availability  

Atazanavir, available under the brand name, Reyataz, is approved by the US FDA to treat HIV infections in adults and children. It is available in two forms: capsules and oral powder.

Atazanavir Structure and Mechanism of Action Atazanavir Structure and Mechanism of Action

The chemical name of Atazanavir is methyl ((5S,8S,9S,14S)-8-benzyl-5-(tert-butyl)-9-hydroxy-15,15-dimethyl-3,6,13-trioxo-11-(4-(pyridin-2-yl)benzyl)-2-oxa-4,7,11,12-tetraazahexadecan-14-yl)carbamate. Its chemical formula is C38H52N6O7, and its molecular weight is approximately 704.9 g/mol.

Atazanavir inhibits the virus-specific processing of viral Gag and Gag-Pol polyproteins in HIV–1 infected cells and prevents mature virions formation.

Atazanavir Impurities and Synthesis

Like any other pharmaceutical compound, Atazanavir can contain impurities generated during its synthetic1 process. These impurities form due to various factors such as raw materials, synthetic procedures, storage, and degradation. Atazanavir impurities are of three types: organic, inorganic, and residual solvents. It is necessary to synthesize and analyze them and the residual solvents present in the drug substance to ensure the safety and efficacy of Atazanavir.

Daicel Pharma offers a Certificate of Analysis (CoA) for Atazanavir impurity standards, which includes (+)-Tert-butyl ((R)-1-((R)-oxiran-2-yl)-2-phenylethyl) carbamate, Atazanavir Hydrazine Analog TFA Salt, and ATAZANAVIR SULFATE ATARC-1. The CoA is produced from a cGMP-compliant analytical facility and includes comprehensive characterization data, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity. Additional characterization data, such as 13C-DEPT and CHN, can also be provided on request. Daicel Pharma can prepare unknown Atazanavir impurities or degradation products and supply labeled compounds to evaluate the effectiveness of Atazanavir. Also, Daicel Pharma offers Atazanavir Labelled Standard, a deuterium-labeled Atazanavir-D6 standard useful in bio-analytical research, such as BA/BE studies. Each delivery has a complete characterization report.

References
FAQ's

Frequently Asked Questions

Analytical testing helps detect impurities in Atazanavir by providing accurate and reliable data on their presence and concentration.

Impurities in Atazanavir can affect its therapeutic efficacy by reducing the drug's potency or altering its mechanism of action.

The impurities in Atazanavir are controlled during storage by ensuring appropriate temperature, humidity, and light conditions, using proper packaging and storage containers.

Atazanavir impurities are stored at a controlled room temperature between 2-8 °C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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