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((S)-1-((S)-2-aminopropanamido)ethyl)phosphonoc acid | Daicel Pharma Standards
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((S)-1-((S)-2-aminopropanamido)ethyl)phosphonic acid

  • CAT Number DCTI-C-1543
  • CAS Number 66023-94-7
  • Molecular Formula C5H13N2O4P
  • Molecular Weight 196.14

(1-((S)-2-aminopropanamido)ethyl)phosphonic acid

  • CAT Number DCTI-C-1544
  • CAS Number NA
  • Molecular Formula C5H13N2O4P
  • Molecular Weight 196.14

benzyl ((2R)-1-((1-(dimethoxyphosphoryl)ethyl)amin...

  • CAT Number DCTI-C-1455
  • CAS Number NA
  • Molecular Formula C15H23N2O6P
  • Molecular Weight 358.33

benzyl ((2S)-1-((1-(dimethoxyphosphoryl)ethyl)amin...

  • CAT Number DCTI-C-1545
  • CAS Number NA
  • Molecular Formula C15H23N2O6P
  • Molecular Weight 358.33

L-Alanyl-L-1aminoethylphosponic acid

  • CAT Number DCTI-C-1546
  • CAS Number 60668-24-8
  • Molecular Formula C5H13N2O4P
  • Molecular Weight 196.14

General Information

Alafosfalin Impurities and Alafosfalin 

Daicel Pharma is a reliable partner for synthesizing high-quality Alafosfalin impurities, specifically ((S)-1-((S)-2-aminopropanamido)ethyl)phosphonic acid, (1-((S)-2-aminopropanamido)ethyl)phosphonic acid, benzyl ((2R)-1-((1-(dimethoxyphosphoryl)ethyl)amino)-1-oxopropan-2-yl)carbamate, benzyl ((2S)-1-((1-(dimethoxyphosphoryl)ethyl)amino)-1-oxopropan-2-yl)carbamate and L-Alanyl-L-1-aminoethylphosponic acid. These impurities help assess the quality, stability, and safety of the active pharmaceutical ingredient, Alafosfalin. Daicel Pharma also offers a custom synthesis of Alafosfalin impurities, which can be shipped worldwide to meet customers’ unique requirements.

Alafosfalin [CAS: 60668-24-8] is a phosphonodipeptide that inhibits bacterial cell wall biosynthesis. It is an antibacterial, effective against many organisms, particularly Gram-negative bacteria.

Alafosfalin: Use and Commercial Availability  

Alafosfalin is a well-known antibacterial agent synthesized by Roche. It has a broad spectrum of antibacterial activity against certain Gram-positive aerobes, anaerobic bacteria, and many species of Enterobacterales. It is highly effective against Escherichia coli and moderately effective against Serratia, Klebsiella, Enterobacter, and Citrobacter. It is bactericidal against Gram-negative bacteria, causing rapid lysis of susceptible strains.

Alafosfalin Structure and Mechanism of Action Alafosfalin Structure and Mechanism of Action

The chemical name of Alafosfalin is (1R)-1-(L-Alanylamino)ethylphosphonic acid. Its chemical formula is C5H13N2O4P, and its molecular weight is approximately 196.14 g/mol.

Alafosfalin bacterial uptake is through LL-dipeptide permeases. Its subsequent hydrolysis yields fosfalin (L-1-aminoethylphosphonic acid). It binds with alanine racemase. Further, it prevents the synthesis of D-alanine, which is essential for peptidoglycan biosynthesis.

Alafosfalin Impurities and Synthesis

There is limited information available on the impurities of Alafosfalin, an antibiotic. However, impurities may form during the synthesis1, storage, and handling of the organic compound. They can impact the efficacy and safety of the drug product. Thus, it is essential to control and minimize impurities during the manufacturing process and ensure appropriate storage conditions to maintain the quality of the drug product.

Daicel Pharma issues a Certificate of Analysis (CoA) for Alafosfalin impurity standards, including ((S)-1-((S)-2-aminopropanamido)ethyl)phosphonic acid, (1-((S)-2-aminopropanamido)ethyl)phosphonic acid, benzyl ((2R)-1-((1-(dimethoxyphosphoryl)ethyl)amino)-1-oxopropan-2-yl)carbamate, benzyl ((2S)-1-((1-(dimethoxyphosphoryl)ethyl)amino)-1-oxopropan-2-yl)carbamate and L-Alanyl-L-1aminoethylphosponic acid. The CoA is from an analytical facility that complies with current Good Manufacturing Practices (cGMP) and includes comprehensive characterization data, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. We give additional characterization data such as 13C-DEPT and CHN on request. Daicel Pharma can prepare unknown Alafosfalin impurities or degradation products. A complete characterization report accompanies each delivery.


Frequently Asked Questions

Impurity standards help calibrate and validate analytical methods for detecting impurities in Alafosfalin, ensuring the accuracy and precision of the results.

Identifying and characterizing unknown Alafosfalin impurities involves many analytical techniques, including HPLC, MS, etc., to determine their chemical structures and toxicity.

Water or Acetonitrile is a solvent used in analyzing many impurities in Alafosfalin.

Alafosfalin impurities are stored at a controlled room temperature between 2-8 ⁰C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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