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2- Bromopropyl Adenine

  • CAT Number DCTI-C-345
  • CAS Number NA
  • Molecular Formula C8H10BrN5
  • Molecular Weight 256.11

2-Chloropropyl Adenine

  • CAT Number DCTI-C-344
  • CAS Number 50615-40-2
  • Molecular Formula C8H10ClN5
  • Molecular Weight 211.65

9-(2-Hydroxy ethyl) adenine

  • CAT Number DCTI-C-1353
  • CAS Number 707-99-3
  • Molecular Formula C7H9N5O
  • Molecular Weight 179.18

General Information

Adenine Impurities and Adenine 

Daicel Pharma synthesizes high-quality Adenine impurities like 2-Bromopropyl Adenine, 2-Chloropropyl Adenine, and 9-(2-Hydroxy ethyl) Adenine, which are crucial in the analysis of the quality, stability, and biological safety of the active pharmaceutical ingredient Adenine. Moreover, Daicel Pharma offers custom synthesis of Adenine impurities and delivers them globally.

Adenine [CAS: 73-24-5] is a purine nucleobase belonging to the class of 6-aminopurines. Adenine is the precursor of two important nucleosides, Adenosine, and deoxyadenosine. These nucleosides are crucial building blocks of DNA and RNA molecules, essential for the proper functioning of cells in living organisms.

Adenine: Use and Commercial Availability  

Adenine is a purine base organic compound that is an essential component of DNA and RNA. It is also present in many multivitamins and is used for nutritional supplementation to address dietary deficiencies or imbalances. Adenine is an active ingredient in many products, including Rejuvesol and CPDA-1.

Adenine Structure and Mechanism of ActionAdenine Structure and Mechanism of Action

The chemical name of Adenine is 9H-Purin-6-amine. Its chemical formula is C5H5N5, and its molecular weight is approximately 135.13 g/mol.

Adenine is a crucial component of Adenine nucleotides and forms Adenosine, a nucleoside when attached to ribose, and deoxyadenosine when attached to deoxyribose. It forms Adenosine triphosphate (ATP) when three phosphate groups add to Adenosine, and it helps in cellular metabolism by transferring chemical energy between chemical reactions.

Adenine Impurities and Synthesis

The impurities in Adenine are classified as organic and inorganic impurities. Organic impurities may include related substances such as Adenine analogs, while inorganic impurities may include heavy metals or other contaminants introduced during synthesis1,2. Impurities can form during the synthesis, isolation, and purification of Adenine. The analysis and control of these impurities are essential to ensure that the final product meets the required quality standards for its intended use, whether for research, pharmaceuticals, or other applications.

Daicel provides a Certificate of Analysis (CoA) for Adenine impurity standards, including 2-Bromopropyl Adenine, 2-Chloropropyl Adenine, and 9-(2-Hydroxy ethyl) Adenine. The CoA is issued from a cGMP-compliant analytical facility and contains complete characterization data3, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity. Additional characterization data, such as 13C-DEPT and CHN, can be provided upon request. Daicel can also prepare any unknown Adenine impurity or degradation product. We give a complete characterization report on delivery.


Frequently Asked Questions

Impurities in Adenine are monitored through regular quality control testing using analytical methods such as HPLC and LC-MS.

Impurities in Adenine affect the drug’s purity, potency, and stability. They can also impact the quality and effectiveness of products made using Adenine.

Impurities in Adenine can be separated through various purification techniques such as chromatography, and recrystallization.

Adenine impurities are stored at a controlled room temperature between 2-8 ⁰C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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