Sort by

Adefovier Dipivoxil Impurity-5

  • CAT Number DCTI-C-798
  • CAS Number NA
  • Molecular Formula C15H24N5O7P
  • Molecular Weight 417.36

Adefovir Dipivoxil Dimer

  • CAT Number DCTI-C-1452
  • CAS Number 323201-05-4
  • Molecular Formula C41H64N10O16P2
  • Molecular Weight 1014.96

Adefovir dipivoxil Impurity-1

  • CAT Number DCTI-C-1431
  • CAS Number 1215101-40-8
  • Molecular Formula C25H40N5O9P
  • Molecular Weight 585.59

Adefovir Dipivoxil N6-Hydroxy methyl impurity

  • CAT Number DCTI-C-736
  • CAS Number 323201-04-3
  • Molecular Formula C21H34N5O9P
  • Molecular Weight 531.5

Adefovir Tripivoxil Dimer Diethylamine salt

  • CAT Number DCTI-C-1105
  • CAS Number NA
  • Molecular Formula C35H54N10O14P2 (Free base) C39H65N11O14P2 (Salt)
  • Molecular Weight 900.82 (Free base) 973.96 (Salt)

General Information

Adefovir Impurities and Adefovir

Daicel Pharma synthesizes high-quality Adefovir impurities like Adefovir dipivoxil Impurity-1, Adefovir Dipivoxil Dimer, Adefovier Dipivoxil Impurity-5, Adefovir Tripivoxil Dimer Diethylamine salt, and Adefovir Dipivoxil N6-Hydroxy methyl impurity, which are crucial in the analysis of the quality, stability, and biological safety of the active pharmaceutical ingredient Adefovir. Moreover, Daicel Pharma offers custom synthesis of Adefovir impurities and delivers them globally.

Adefovir [CAS: 106941-25-7] is an analog of Adenosine inhibiting the reverse transcriptase enzyme. It has antiviral activity against the hepatitis B virus, herpes virus, and human immunodeficiency virus (HIV). Adefovir dipivoxil is a prodrug of Adefovir that treats chronic hepatitis B alone or in combination with other medicines.

Adefovir: Use and Commercial Availability  

Adefovir is an acyclic analog of Adenosine. It treats chronic hepatitis B either alone or in combination with other drugs. It is available in the market under Hepsera and Adefovir Dipivoxil. Adefovir inhibits the replication of the hepatitis B virus, reducing the amount of virus in the body and slowing down the progression of the disease.

Adefovir Structure and Mechanism of Action Adefovir Structure and Mechanism of Action

The chemical name of Adefovir is 2-(6-Aminopurin-9-yl)ethoxymethylphosphonic acid. Its chemical formula is C8H12N5O4P, and its molecular weight is approximately 273.19 g/mol.

Adefovir is converted to its metabolite adefovir diphosphate by adenylate kinase through phosphorylation reactions. It inhibits viral DNA polymerase.

Adefovir Impurities and Synthesis

Like other drugs, Adefovir may contain impurities that can affect its purity, potency, and safety. Impurities in Adefovir arise from various sources, including the starting materials, synthetic processess1,2, and storage conditions. The common impurities in Adefovir include related substances, residual solvents, and heavy metals. The control of Adefovir impurities is necessary to ensure its quality, safety, and efficacy, as well as to comply with regulatory requirements.

Daicel provides a Certificate of Analysis (CoA) for Adefovir impurity standards, including Adefovir dipivoxil Impurity-1, Adefovir Dipivoxil Dimer, Adefovier Dipivoxil Impurity-5, Adefovir Tripivoxil Dimer Diethylamine salt, and Adefovir Dipivoxil N6-Hydroxy methyl impurity. The CoA is issued from a cGMP-compliant analytical facility and contains complete characterization data, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity3. Additional characterization data, such as 13C-DEPT and CHN, can be provided upon request. Daicel can also prepare any unknown Adefovir impurity or degradation product. We give a complete characterization report on delivery.


Frequently Asked Questions

The degradation products in Adefovir include impurities formed due to degradation processes, such as hydrolysis, oxidation, and photodegradation.

Impurities in Adefovir are detected and quantified using analytical methods such as high-performance liquid chromatography (HPLC) and Liquid chromatography-mass spectrometry (LC-MS).

Methanol is a solvent used in analyzing many impurities in Adefovir.

Adefovir impurities are stored at a controlled room temperature between 2-8 ⁰C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

Back to Top
Product has been added to your cart