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(R )-Acenocoumarol

  • CAT Number DCTI-C-729
  • CAS Number 66556-77-2
  • Molecular Formula C19H15NO6
  • Molecular Weight 353.33


  • CAT Number DCTI-C-730
  • CAS Number 66556-78-3
  • Molecular Formula C19H15NO6
  • Molecular Weight 353.33


  • CAT Number DCTI-A-218
  • CAS Number NA
  • Molecular Formula C19H10D5NO6
  • Molecular Weight 358.36

General Information

Acenocoumarol Impurities and Acenocoumarol 

Daicel Pharma synthesizes high-quality Acenocoumarol impurities like (R)-Acenocoumarol and (S)-Acenocoumarol, which is crucial in analyzing the quality, stability, and biological safety of the active pharmaceutical ingredient Acenocoumarol. Moreover, Daicel Pharma offers custom synthesis of Acenocoumarol impurities and delivers them globally.

Acenocoumarol [CAS: 152-72-7] is a 4-hydroxycoumarin derivative, an anticoagulant medicine. It antagonizes vitamin K, similar to warfarin, and thus has anticoagulant properties. One advantage of using Acenocoumarol over other anticoagulants, such as warfarin and phenprocoumon, is the shorter duration of action, which is beneficial in case of bleeding.

Acenocoumarol: Use and Commercial Availability

Acenocoumarol is a medicine that treats and prevents thromboembolic diseases, including deep vein thrombosis, pulmonary embolism, cerebral embolism, and thromboembolism in infarction and transient ischemic attacks. In India, the drug is available under the trade names Acitrom and Nistrom.

Acenocoumarol Structure and Mechanism of ActionAcenocoumarol Structure and Mechanism of Action

The chemical name of Acenocoumarol is 4-Hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one. Its chemical formula is C19H15NO6, and its molecular weight is approximately 353.3 g/mol.

Acenocoumarol inhibits Vitamin K reduction. It prevents carboxylation of glutamic acid residues, Vitamin K-dependent clotting factors.

Acenocoumarol Impurities and Synthesis

During the production of Acenocoumarol, impurities arise from the starting materials, synthetic process, or degradation of the drug substance. These impurities harm the drug’s safety and efficacy, hence monitoring and controlling the level of Acenocoumarol impurities is essential.

Daicel provides a Certificate of Analysis (CoA) for Acenocoumarol impurity standards, (R)-Acenocoumarol and (S)-Acenocoumarol. The CoA is issued from a cGMP-compliant analytical facility and contains complete characterization data, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity1,2. Additional characterization data, such as 13C-DEPT and CHN, can be provided upon request. Daicel can also prepare any unknown Acenocoumarol impurity or degradation product and offer labeled compounds to quantify the efficacy of generic Acenocoumarol. Daicel offers Acenocoumarol-D5, a deuterium-labeled Acenocoumarol standard used in bio-analytical research, such as BA/BE studies. We give a complete characterization report on delivery.


Frequently Asked Questions

Residual solvents in Acenocoumarol are volatile substances used during manufacturing and may remain in the final drug product.

Impurities in Acenocoumarol are detected using analytical techniques such as Reverse-phase high-performance liquid chromatography (RP-HPLC).

Acetonitrile is the solvent used in analyzing many impurities in Acenocoumarol.

Acenocoumarol impurities are stored at a controlled room temperature between 2-8 ⁰C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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