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(3b-acetoxy-17-iodoandrosta-5,16-diene) (A52H)

  • CAS NUMBER 114611-53-9

Abiraterone Acetate Impurity

  • CAT Number DCTI-A-021
  • CAS Number 154229-19-3
  • Molecular Formula C24H31NO
  • Molecular Weight 349.52

Abiraterone Acetate Reduced Impurity

  • CAT Number DCTI-C-710
  • CAS Number 219843-75-1
  • Molecular Formula C24H33NO
  • Molecular Weight 351.53

Abiraterone acetate reduced impurity

  • CAT Number DCTI-C-924
  • CAS Number 2141996-19-0
  • Molecular Formula C26H35NO2
  • Molecular Weight 393.57

Abiraterone acetate-D3

  • CAT Number DCTI-A-168
  • CAS Number 2122245-10-5
  • Molecular Formula C26H30D3NO2
  • Molecular Weight 394.57

Abiraterone Dimer Impurity

  • CAT Number DCTI-C-1239
  • CAS Number 186826-70-0
  • Molecular Formula C43H57NO2
  • Molecular Weight 619.93

Abiraterone Ethyl Ether

  • CAT Number DCTI-C-244
  • CAS Number 2484719-14-2
  • Molecular Formula C26H35NO
  • Molecular Weight 377.57

Abiraterone Impurity 5

  • CAT Number DCTI-C-1717
  • CAS Number 32138-69-5
  • Molecular Formula C19H27IO
  • Molecular Weight 398.32

Abiraterone Methyl Ether

  • CAT Number DCTI-C-243
  • CAS Number 1470276-23-3
  • Molecular Formula C25H33NO
  • Molecular Weight 363.55
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General Information

Abiraterone Impurities and Abiraterone  

Daicel Pharma synthesizes high-quality Abiraterone impurities like Abiraterone Acetate Impurity, Abiraterone Dimer Impurity, Abiraterone Ethyl Ether, Abiraterone Methyl Ether, Abiraterone propionate Impurity, Abiraterone Sulfate, and more, which are crucial in the analysis of the quality, stability, and biological safety of the active pharmaceutical ingredient Abiraterone. Moreover, Daicel Pharma offers custom synthesis of Abiraterone impurities and delivers them globally.

Abiraterone [CAS: 154229-19-3] is a steroidal compound having antiandrogenic properties. Abiraterone is a medicine that treats metastatic prostate cancer in men who have undergone castration. It inhibits the activity of steroid 17 alpha-monooxygenase, also known as CYP17A1. This enzyme is a member of the cytochrome p450 family and helps in testosterone synthesis.

Abiraterone: Use and Commercial Availability  

Abiraterone, available under the trade name Zytiga, was the first drug to work through its mechanism. It is an irreversible inhibitor of the enzyme CYP17A1, crucial for androgens and estrogens preparation in both the adrenal glands and tumor tissues. Therefore, Abiraterone suppresses androgen synthesis in both of these locations. Abiraterone is available as abiraterone acetate combines with either methylprednisolone or prednisone and treats metastatic castration-resistant prostate cancer (CRPC) or metastatic high-risk castration-sensitive prostate cancer (CSPC). The other trade name of Abiraterone is Yonsa.

Abiraterone Structure and Mechanism of ActionAbiraterone Structure and Mechanism of Action

The chemical name of Abiraterone is (3β)-17-(3-Pyridinyl)androsta-5,16-dien-3-ol. Its chemical formula is C24H31NO, and its molecular weight is approximately 349.5 g/mol.

Abiraterone inhibits 17 α-hydroxylase/C17,20-lyase (CYP17) enzyme expressed in testicular, adrenal, and prostatic tumor tissues. It is for androgen biosynthesis.

Abiraterone Impurities and Synthesis

The most common Abiraterone impurities are related to the starting materials used in the synthetic process1. Impurities can form during the reaction process or as a result of the degradation of the drug substance. Controlling these impurities is vital for maintaining drug quality, safety, and efficacy.

Daicel provides a Certificate of Analysis (CoA) for Abiraterone impurity standards, including Abiraterone Acetate Impurity, Abiraterone Dimer Impurity, Abiraterone Ethyl Ether, Abiraterone Methyl Ether, Abiraterone propionate Impurity, Abiraterone Sulfate, and more. The CoA is issued from a cGMP-compliant analytical facility and contains complete characterization data, such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2,3. Additional characterization data, such as 13C-DEPT and CHN, can be provided upon request. Daicel can also prepare any unknown Abiraterone impurity or degradation product and offer labeled compounds to quantify the efficacy of Abiraterone. Daicel offers Abiraterone acetate-D3, a deuterium-labeled Abiraterone compound used in bio-analytical research such as BA/BE studies. We give a complete characterization report on delivery.


Frequently Asked Questions

The impurities in Abiraterone affect the drug's efficacy and safety.

The types of impurities in Abiraterone are categorized into organic impurities, inorganic impurities, residual solvents, and potential genotoxic impurities.

The impurities in Abiraterone were detected using analytical techniques such as high-performance liquid chromatography (HPLC) and LC–UV.

Abiraterone impurities are stored at a controlled room temperature between 2-8 ⁰C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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