Vortioxetine

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N-Nitroso Vortioxetine-D8

  • CAT NUMBER DCTI-A-370
  • CAS NUMBER NA
  • MOLECULAR FORMULA C18H13D8N3OS
  • MOLECULAR WEIGHT 335.49

N-Nitroso-Vortioxetine

  • CAT NUMBER DCTI-C-3417
  • CAS NUMBER 2925447-38-5
  • MOLECULAR FORMULA C18H21N3OS
  • MOLECULAR WEIGHT 327.45

Vortioxetine Metabolite HCl salt

  • CAT NUMBER DCTI-C-3294
  • CAS NUMBER 1429751-00-7 (Free Base)
  • MOLECULAR FORMULA Free Base:C18H22N2OS; HCl salt:C18H23ClN2OS
  • MOLECULAR WEIGHT Free Base:314.45; HCl Salt:350.91

Vortioxetine N-Formyl Impurity

  • CAT Number DCTI-C-014
  • CAS Number 2135576-73-5
  • Molecular Formula C19H22N2OS
  • Molecular Weight 326.46

Vortioxetine N-Methyl Impurity

  • CAT Number DCTI-C-013
  • CAS Number  1293489-87-8
  • Molecular Formula C19H25ClN2S (HCl Salt) C19H24N2S (Free base)
  • Molecular Weight 348.93 (HCl Salt) 312.48 (Free base)

Vortioxetine-D8

  • CAT Number DCTI-A-053
  • CAS Number 2140316-62-5
  • Molecular Formula C18H14D8N2S
  • Molecular Weight 306.5

General Information

Vortioxetine Impurities and Vortioxetine

Daicel Pharma is a reliable supplier of high-quality impurity standards for Vortioxetine, which includes Vortioxetine N-Formyl Impurity and Vortioxetine N-Methyl Impurity. These impurities are critical in thoroughly assessing the quality, stability, and safety of the active pharmaceutical ingredient, Vortioxetine. Moreover, Daicel Pharma provides Vortioxetine impurities to meet client requirements with utmost precision. With worldwide shipping capabilities, customers can conveniently receive these impurities anywhere, ensuring unparalleled convenience.

Vortioxetine [CAS: 508233-74-7] is a serotonergic antidepressant of a class of drugs known as serotonin modulators. It treats MDD (Major Depressive Disorder) in adults.

Vortioxetine: Use and Commercial Availability

Vortioxetine is a medication used to treat major depressive disorder (MDD) in adults. It affects the neurotransmitter levels in the brain. It can help alleviate the symptoms of depression, such as persistent sadness, loss of interest, changes in appetite or sleep patterns, and lack of energy. Vortioxetine is available under the brand name, Brintellix, which contains the active ingredient, Vortioxetine.

Vortioxetine Structure and Mechanism of ActionVortioxetine Structure and Mechanism of Action

The chemical name of Vortioxetine is 1-[2-[(2,4-Dimethylphenyl)thio]phenyl]piperazine. Its chemical formula is C18H22N2S, and its molecular weight is approximately 298.4 g/mol.

Vortioxetine enhances serotonergic activity in the CNS by inhibiting serotonin reuptake.

Vortioxetine Impurities and Synthesis

Vortioxetine impurities can arise during synthesis1 due to the storage or use of specific raw materials and intermediates in manufacturing. These impurities encompass related compounds, degradation products, and process impurities. Stringent quality control measures and analytical methods are crucial to ensure the purity and safety of Vortioxetine for patient use.

Daicel Pharma provides a comprehensive Certificate of Analysis (CoA) for Vortioxetine impurity standards, such as Vortioxetine N-Formyl Impurity and Vortioxetine N-Methyl Impurity. The CoA includes detailed characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. Additionally, upon delivery, we give 13C-DEPT. Daicel possesses the technology and expertise to synthesize any unknown Vortioxetine impurity or degradation product. We also offer labeled compounds to quantify the efficacy of generic Vortioxetine. For bioanalytical research and BA/BE studies, Daicel also supplies Vortioxetine-D8, a deuterium-labeled Vortioxetine compound.

References
FAQ's

Frequently Asked Questions

Some providers specialize in customizing Vortioxetine impurities to meet client specifications.

Yes, certain impurities in Vortioxetine can potentially pose risks to patients and is essential to detect them.

Vortioxetine impurities are identified and characterized using advanced analytical techniques such as mass spectrometry (MS).

The recommendation is to store Vortioxetine impurities at room temperature, within 2-8 °C.

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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