Propofol

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1-methylethyl 4-hydroxy-3,5-bis (1-methylethyl)benzoate

  • CAT NUMBER DCTI-C-3235
  • CAS NUMBER 2095678-97-8
  • MOLECULAR FORMULA C16H24O3
  • MOLECULAR WEIGHT 264.37

2,4-bis(1-methylethyl)phenol

  • CAT NUMBER DCTI-C-3224
  • CAS NUMBER 5/6/2934
  • MOLECULAR FORMULA C12H18O
  • MOLECULAR WEIGHT 178.28

Propofol EP impurity-K

  • CAT Number DCTI-C-842
  • CAS Number 14366-59-7
  • Molecular Formula C12H18O
  • Molecular Weight 178.28

Propofol EP impurity-L

  • CAT Number DCTI-C-843
  • CAS Number 201166-22-5
  • Molecular Formula C12H16O2
  • Molecular Weight 192.26

Propofol EP impurity-O

  • CAT Number DCTI-C-844
  • CAS Number 74663-48-2
  • Molecular Formula C12H18O
  • Molecular Weight 178.28

General Information

Propofol Impurities and Propofol

Daicel Pharma offers Propofol impurity standards, which include Propofol EP impurity-K, Propofol EP impurity-L, and Propofol EP impurity-O. Their presence can influence the effectiveness, stability, and safety of Propofol. Daicel Pharma offers custom synthesis for Propofol impurities and provides international delivery.

Propofol [CAS: 2078-54-8] is a phenol that acts as an anesthetic and for managing refractory status epilepticus.

Propofol: Use and Commercial Availability 

Propofol is an anesthetic drug that is injected intravenously during general anesthesia. It acts as a sedative and an anticonvulsant. It also keeps patients in a coma in critical care units (ICUs). This drug is available under tradenames such as Diprivan.

Propofol Structure and Mechanism of ActionPropofol Structure and Mechanism of Action

The chemical name of Propofol is 2,6-Bis(1-methylethyl)phenol. Its chemical formula is C12H18O, and its molecular weight is approximately 178.27 g/mol.

Propofol inhibits the functioning of the neurotransmitter gamma-aminobutyric acid (GABA).

Propofol Impurities and Synthesis

Impurities in Propofol are unwanted chemicals present as unexpected byproducts of the synthetic1 process, or they get introduced during production or storage. These impurities may influence the drug’s quality, safety, and efficacy.

Daicel Pharma offers a Certificate of Analysis (CoA) for Propofol impurity standards such as Propofol EP impurity-K, Propofol EP impurity-L, and Propofol EP impurity-O, from an analytical facility that is cGMP-compliant. Daicel Pharma provides a CoA with comprehensive characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. Additional characterization details, including 13C-DEPT, can be provided upon request. At Daicel Pharma, our team of experts can provide impurities and labeled compounds of Propofol to assess generic Propofol.

References
FAQ's

Frequently Asked Questions

A cGMP-certified analytical laboratory helps ensure the quality and safety of the drug while detecting Propofol impurities.

Propofol impurities can arise in the drug as unintended byproducts of the synthetic process or as impurities introduced during manufacturing or storage.

Propofol impurities are monitored through various steps in clinical settings.

Propofol impurities are stored preferably at a regulated room temperature of 2-8°C or as specified on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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