Latrepirdine

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Latrepirdine Impurity 2

  • CAT NUMBER DCTI-C-2667
  • CAS NUMBER 1147893-81-9
  • MOLECULAR FORMULA C21H23N3O2
  • MOLECULAR WEIGHT 349.43

Latrepirdine Impurity-1

  • CAT NUMBER DCTI-C-2668
  • CAS NUMBER 23224-24-0
  • MOLECULAR FORMULA C20H23N3
  • MOLECULAR WEIGHT 305.43

Latrepirdine N-oxide

  • CAT NUMBER DCTI-C-2669
  • CAS NUMBER 1147893-84-2
  • MOLECULAR FORMULA C21H25N3O
  • MOLECULAR WEIGHT 335.45

General Information

Latrepirdine Impurities and Latrepirdine

Daicel Pharma offers worldwide delivery options for custom synthesis of Latrepirdine impurities, including impurity standards, such as Latrepirdine Impurity 2, Latrepirdine Impurity-1, and Latrepirdine N-oxide. These impurities play a vital role in evaluating the purity and safety of Latrepirdine, an active pharmaceutical ingredient.

Investigated for its potential therapeutic benefits, Latrepirdine [CAS: 3613-73-8] is a compound belonging to the methylpyridines and pyridoindole class. It treats Alzheimer’s Disease and Huntington’s Disease.

Latrepirdine: Use and Commercial Availability 

Latrepirdine was initially marketed as a non-selective antihistamine in Russia and later repurposed as a treatment for Alzheimer’s disease (AD) and Huntington’s disease (HD). However, due to its wide range of neuronal functions, exploring the synthesis of structurally similar compounds and investigating their effects on therapeutic targets could lead to novel dementia treatments.

Latrepirdine Structure and Mechanism of ActionLatrepirdine Structure and Mechanism of Action

The chemical name of Latrepirdine is 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-1H-pyrido[4,3-b]indole. Its chemical formula is C21H25N3, and its molecular weight is approximately 319.4 g/mol.

Latrepirdine blocks H1 histamine receptor activity. It also affects coronary blood flow and myocardial contractibility. The drug’s exact mechanisms of action and how it contributes to clinical benefits remain uncertain.

Latrepirdine Impurities and Synthesis

Latrepirdine is a medication that treats Alzheimer’s disease. As with any pharmaceutical compound, Latrepirdine can contain impurities. Impurities in latrepirdine can arise from the manufacturing process1 or external factors. Common Latrepirdine impurities in formulations include related compounds, such as isomers or degradation products. They can result from synthesis, storage conditions, or interactions with other substances. It is crucial for pharmaceutical manufacturers to carefully monitor and control the levels of impurities in latrepirdine to ensure its safety and efficacy. Strict quality control measures help minimize them and maintain the highest pharmaceutical standards for Latrepirdine.

Daicel Pharma strictly adheres to cGMP standards and operates an analytical facility for preparing Latrepirdine impurity standards. We provide a range of Latrepirdine impurity standards, such as Latrepirdine Impurity 2, Latrepirdine Impurity-1, and Latrepirdine N-oxide. Our impurities have a detailed Certificate of Analysis (CoA) and a comprehensive characterization report. The CoA encompasses data obtained through techniques, 1H NMR, 13C NMR, IR, MASS, and HPLC purity analysis. We give additional data, such as 13C-DEPT, upon request. We can synthesize unknown Latrepirdine impurities or degradation products. Each delivery has a comprehensive characterization report.

References
FAQ's

Frequently Asked Questions

Appropriate packaging materials protect Latrepirdine from exposure to light, moisture, and other environmental factors and can help control impurities during packaging.

The choice of the manufacturing process can influence the impurity profile of Latrepirdine. Different synthetic routes or variations in reaction conditions can lead to varying impurity profiles.

Purification techniques such as recrystallization, column chromatography, filtration, and extraction can remove impurities from Latrepirdine.

The recommendation is to store Latrepirdine impurities at a controlled room temperature, within 2-8 °C.

 

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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