Carvedilol

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(R)- N-Benzyl Carvedilol

  • CAT NUMBER DCTI-C-2284
  • CAS NUMBER 224782-76-7
  • MOLECULAR FORMULA C31H32N2O4
  • MOLECULAR WEIGHT 496.61

(R)-(+)-Carvedilol

  • CAT NUMBER DCTI-C-2278
  • CAS NUMBER 95093-99-5
  • MOLECULAR FORMULA C24H26N2O4
  • MOLECULAR WEIGHT 406.48

(S)- N-Benzyl Carvedilol

  • CAT NUMBER DCTI-C-2285
  • CAS NUMBER 224782-73-4
  • MOLECULAR FORMULA C31H32N2O4
  • MOLECULAR WEIGHT 496.61

(S)-(-)-Carvedilol

  • CAT NUMBER DCTI-C-2277
  • CAS NUMBER 95094-00-1
  • MOLECULAR FORMULA C24H26N2O5
  • MOLECULAR WEIGHT 406.48

Carvedilol Bisalkylpyrocatechol impurity. TFA salt

  • CAT NUMBER DCTI-C-2276
  • CAS NUMBER NA
  • MOLECULAR FORMULA C42H43F3N4O8 (TFA Salt); C40H43N4O6 (free Base)
  • MOLECULAR WEIGHT 788.82 (TFA Salt); 674.80 (free base)

Carvedilol Biscarbazole Impurity

  • CAT NUMBER DCTI-C-2353
  • CAS NUMBER 1276477-91-8
  • MOLECULAR FORMULA C27H22N2O3
  • MOLECULAR WEIGHT 422.48

Carvedilol EP Impurity B

  • CAT NUMBER DCTI-C-2355
  • CAS NUMBER 918903-20-5
  • MOLECULAR FORMULA C39H39N3O6
  • MOLECULAR WEIGHT 645.76

Carvedilol EP Impurity D

  • CAT NUMBER DCTI-C-2304
  • CAS NUMBER 1391052-16-6
  • MOLECULAR FORMULA C39H39N3O6
  • MOLECULAR WEIGHT 645.76

Carvedilol EP impurity E .HCl salt

  • CAT NUMBER DCTI-C-2270
  • CAS NUMBER 1836-62-0 (free base)
  • MOLECULAR FORMULA C9H13NO2 (free base); C9H13NO2·HCl (HCl salt)
  • MOLECULAR WEIGHT 167.21 (free base); 203.67 (HCl salt)
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General Information

Carvedilol Impurities and Carvedilol

Daicel Pharma synthesizes Carvedilol impurities of exceptional quality, such as (R)- N-Benzyl Carvedilol, (R)-(+)-Carvedilol, (S)- N-Benzyl Carvedilol, and more. These impurities are crucial to assess the purity, reliability, and safety of Carvedilol, an active pharmaceutical ingredient. Besides, Daicel Pharma provides custom synthesis of Carvedilol impurities to meet clients’ demands for delivery worldwide.

Carvedilol [CAS: 72956-09-3] is a third-generation beta-blocker treating mild to severe heart failure. It can block beta1 and beta2 receptors and also exhibits alpha1-adrenergic blocking properties. This drug treats conditions such as high blood pressure, stable angina pectoris, and congestive heart failure.

Carvedilol: Use and Commercial Availability  

Carvedilol is a non-selective adrenergic blocker that treats congestive heart failure. It also treats hypertension and stable angina pectoris. It is a highly lipophilic non-selective beta-adrenoceptor antagonist. It has alpha1-blocking action, promotes peripheral vasodilatation, and also possesses free radical scavenging and antimitogenic effects. The drug is available under Carvedilol Phosphate, Coreg, and Coreg CR.

Carvedilol Structure and Mechanism of Action Carvedilol Structure and Mechanism of Action

The chemical name of Carvedilol is 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol. Its chemical formula is C24H26N2O4, and its molecular weight is approximately 406.5 g/mol.

Carvedilol has alpha1-adrenergic receptor antagonist properties with peripheral vasodilating effects. It inhibits apoptosis and reduces vascular smooth muscle migration.

Carvedilol Impurities and Synthesis

During the synthesis1 and storage of Carvedilol, impurities can form, which affect the drug’s efficacy and safety. It is vital to control and monitor these impurities as they can alter the pharmacological profile of the drug, leading to potential adverse effects. The International Council for Harmonization (ICH) guidelines provide specific limits for these impurities to ensure the safety and quality of the drug product. Thus, rigorous testing and monitoring of Carvedilol impurities are necessary to ensure its safety and efficacy.

Daicel Pharma offers a Certificate of Analysis (CoA) for Carvedilol impurity standards, such as (R)- N-Benzyl Carvedilol, (R)-(+)-Carvedilol, (S)- N-Benzyl Carvedilol, and more, generated from an analytical facility compliant with cGMP standards. The CoA includes a comprehensive characterization report comprising data from various techniques like 1H NMR, 13C NMR, IR, MASS, and HPLC purity2. Furthermore, we can give additional data like 13C-DEPT and CHN on request. Daicel Pharma can synthesize unknown Carvedilol impurities or degradation products and labeled compounds to assess the effectiveness of Carvedilol. We also give highly pure deuterium-labeled Carvedilol Labelled Standard for bioanalytical research such as BA/BE studies. A complete characterization report accompanies every delivery.

References
FAQ's

Frequently Asked Questions

Impurities in Carvedilol are identified using analytical techniques such as high-performance liquid chromatography (HPLC), liquid chromatography (LC), mass spectrometry (MS), etc.

The limits for impurities in Carvedilol set by regulatory agencies are  ≤0.2% for individuals and ≤0.5% for total impurities.

Impurity standards in Carvedilol help identify and quantify impurities in the drug substance. They are also used to develop and validate analytical methods for impurity identification and quantification.

Carvedilol impurities are stored at a controlled room temperature between 2-8 °C or as indicated on the Certificate of Analysis (CoA).

Note: Products protected by valid patents by a manufacturer are not offered for sale in countries having patent protection. The sale of such products constitutes a patent infringement, and its liability is at the buyer's risk.

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